ArticleInternational journal of surgery (London, England)2026
3,4-Dimethoxychalcone-induced caloric restriction inhibits PANoptosis to promote ischemic and diabetic skin flap survival: experimental studies.
Article in International journal of surgery (London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed.
- Endothelial miR-15a/16-1 Regulation of SYNE1 Mediates Structural and Functional Recovery after Traumatic Brain Injury.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- A Review on Structural Insights into NLRP3 and NEK7: Domain Architecture, Subcellular Localization, and Their Interaction in Inflammasome Assembly and Signaling.Molecular neurobiology · 2026Review
- Dissecting PANoptosis in the Nervous System: A Unified Cell-Death Mechanism Driving Neuroimmune Activation and Chronic Neuroinflammation.Molecular neurobiology · 2026Review
- An SSK1-loaded decellularized annulus fibrosus matrix-based PD hydrogel alleviates intervertebral disc degeneration through modulation of NF-κB signaling and ferroptosis.Journal of orthopaedic translation · 2026Article
- 1,8-Cineole Promotes the Proliferation of Neural Stem Cells and Inhibits Oxidative Damage Induced by Ischemic Stroke via the Wnt/β-Catenin Signaling Pathway.Molecular neurobiology · 2026Article
- A Comprehensive Review on the Microbial Signatures and Metabolic Mechanisms Underlying the Gut-Alzheimer's Disease Axis.Molecular neurobiology · 2026Review
- AMPK-NLRP3 Inflammasome Crosstalk: Structural Insights, Molecular Mechanisms, and Therapeutic Implications for Inflammation and Neuroinflammation.Molecular neurobiology · 2026Review
- DJ-1 in the Neuro-cutaneous Aging Axis: Unifying Pathways of Parkinson's Disease Neurodegeneration, Progression, and Redox-Based Therapeutic Strategies for Healthy Longevity.Molecular neurobiology · 2026Review
- Mitochondrial-Inflammatory Axis Dysregulation Triggers Disulfidptosis and the Multifaceted Protective Mechanism of Bisphenol A Following Spinal Cord Injury.Molecular neurobiology · 2026Article
- Disruption of upstream ox-LDL signaling and HSP90-mediated NLRP3 stability protects against experimental steatohepatitis.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Current status and future prospects of functionalized mesenchymal stem cells for the treatment of spinal cord injury.Journal of orthopaedic translation · 2026Review
- Targeting Interleukin-6 Signaling with Reactive-Oxygen-Species-Responsive Hydrogel to Promote Regeneration after Spinal Cord Injury.Biomaterials research · 2026Article
- Lysosomal membrane permeabilization is involved in CYP2E1-induced apoptosis in hepatocellular carcinoma cells.BBA advances · 2026Article
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIschemic necrosis frequently affects the distal portion of skin flaps, particularly in diabetic patients. PANoptosis, a form of inflammatory programmed cell death, is implicated in vascular damage. This study examined whether 3,4-dimethoxychalcone (3,4-DC), a novel caloric restriction (CR) mimetic, could inhibit PANoptosis and promote the survival of ischemic and diabetic flaps.
methodsFlap viability was evaluated using laser Doppler blood flow imaging and histological analysis. Western blotting and immunofluorescence were used to assess PANoptosis and autophagy. Quantitative PCR was used to measure microRNA levels. Caspase-1 knockout and db/db mice were used to explore the effects of 3,4-DC on pyroptosis and diabetic complications.
results3,4-DC significantly improved ischemic flap survival and enhanced tissue perfusion. PANoptosis was inhibited, and autophagy was activated following 3,4-DC treatment, whereas these effects were abolished by the autophagy inhibitor chloroquine. Transcription factor EB (TFEB) inhibition reduced autophagy and reversed the protective effects of 3,4-DC. miR-107-3p was identified as a 3,4-DC-responsive microRNA that modulates TFEB nuclear translocation through the miR-107-3p/Wnt3a/mTOR pathway. Similar therapeutic effects were observed in diabetic flaps.
conclusion3,4-DC promotes the survival of ischemic and diabetic skin flaps by activating autophagy and inhibiting PANoptosis through the miR-107-3p/Wnt3a/mTOR/TFEB axis.
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