ArticleJournal of cosmetic dermatology2026
Topical Volumizing Cream Improves Facial Volume and Skin Health in Adults With Rapid Weight Loss From Pharmacologic (GLP-1/GIP Agonists), Surgical, or Behavioral Interventions.
Article in Journal of cosmetic dermatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
7 authors.
Funding
Abstract
backgroundGLP-1 receptor agonists (GLP-1) and dual GLP-1/gastric inhibitory polypeptide (GIP) agonists emerged in recent years to promote weight loss. By reducing subcutaneous fat, collagen, and overall structural support of the skin, rapid weight loss can lead to visual face aging.
aimsThis study investigates the synergistic effect of a multi-ingredient topical that acts on different skin levels to treat facial aging in individuals experiencing rapid weight loss from GLP-1 and GIP/GLP-1 agonist use. PATIENTS/
methodsIn this 12-week study, 33 participants from the Sacramento region were given the same topical volumizing cream (Vol.U.Lift, Image Skincare). Participants had 6 visits: screening, baseline, weeks 2, 4, 8, and 12. Tolerability assessments, facial photography, and measurements of hydration, elasticity, and wrinkles were acquired.
results29 subjects completed all study related procedures. Wrinkle severity appearance decreased at week 4 (14.5%, p < 0.001) and 12 (20.7%, p < 0.001). The ultrasound based skin and subcutaneous thickness increased at week 4 (17.3%, p = 0.04) and 12 (20.1%, p = 0.015); TEWL decreased at week 4 (10.39%, p ≤ 0.02) and 12 (12.7%, p ≤ 0.02); Skin hydration increased at week 2 (21.29%, p ≤ 0.01), 4 (19.50%, p ≤ 0.02), and week 12 (21.8%, p ≤ 0.02); Firmness (22.5%, p ≤ 0.002), viscoelasticity (13.1%, p ≤ 0.02) and net elasticity (23.2%, p ≤ 0.0002) increased at week 12.
conclusionsThe use of a topical volumizing cream improved the appearance of facial volume, wrinkles, and biophysical characteristics in participants who had undergone rapid weight loss primarily due to GLP-1/GIP agonist use.
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