ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026
Stepwise Regulation of Cellular Oxidative Stress via Conductive-Piezoelectric Integrated Microstructured Conduits for Enhanced Nerve Regeneration.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Smart-responsive electrospun scaffolds (SRES) for neural repair: Recent advances and future prospects.Bioactive materials · 2026Review
- An implantable mechano-electro cascade platform synchronizes neuro-muscle repair.Nature communications · 2026Article
- Bilayer nerve guidance conduits for continuous delivery of NGF@ZIF-8 nanoparticles for peripheral nerve injury repair.Journal of nanobiotechnology · 2026Article
- Low-Intensity Pulsed Ultrasound in Peripheral and Central Nerve Repair: Mechanisms and Emerging Therapeutic Strategies.Journal of functional biomaterials · 2026Review
- Immunoengineering in the field of tendon and bone regeneration: immunomodulatory biomaterials, delivery platforms, and preclinical models for chronic diseases.Frontiers in bioengineering and biotechnology · 2026Review
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Peripheral nerve injury (PNI) poses significant challenges due to the complex structure and regenerative microenvironment of peripheral nerves, which limit self-repair capabilities. Artificial nerve conduits have been widely used for nerve repair. Here, a conductive-piezoelectric integrated microstructured conduit is designed, using poly(lactic glycolic acid) (PLGA) and poly(vinylidene fluoride) (PVDF) via electrostatic spinning to obtain an implantable, biodegradable piezoelectric nanofibrous membrane. This membrane is further enhanced with a reduced graphene oxide/methacrylated gelatin (rGO/GelMA) gel, which synergistically promotes peripheral nerve repair. In vitro assessments reveal that the microgroove surface pattern of the conduit effectively stimulated the directional migration of cells. Moreover, using a rat sciatic nerve injury model, rGO is demonstrated to significantly modulate cellular oxidative stress, thereby facilitating nerve repair. Additionally, mild electrical stimulation induced by low-intensity pulsed ultrasound (LIPUS) is found to enhance the recovery of motor function. These findings demonstrate the multifaceted benefits of the rGO/GelMA@PVGA composite conduit, which integrates physical guidance, oxidative stress inhibition, and ultrasound-activated electrical stimulation, providing an unprecedented multimodal synergistic strategy with great potential for clinical treatment of peripheral nerve injury.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.