Evidence map›Paper›PMID 41556987›Full record

ArticleArchives of microbiology2026

The antibacterial mechanism of the extracellular product derived from Heyndrickxia coagulans against Staphylococcus aureus.

Keran Jia, Yaqian Yan, Ji Yin, Changtao Wang, Dongdong Wang, Dan Zhao, Jiachan Zhang, Meng Li

Abstract read
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Article in Archives of microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Keran Jia *School of Light Industry Science and Engineering, Beijing Technology and Business University, Beijing, China.
Yaqian Yan *School of Light Industry Science and Engineering, Beijing Technology and Business University, Beijing, China.
Ji YinSchool of Light Industry Science and Engineering, Beijing Technology and Business University, Beijing, China.
Changtao WangSchool of Light Industry Science and Engineering, Beijing Technology and Business University, Beijing, China.
Dongdong WangSchool of Light Industry Science and Engineering, Beijing Technology and Business University, Beijing, China.
Dan ZhaoSchool of Light Industry Science and Engineering, Beijing Technology and Business University, Beijing, China.
Jiachan ZhangSchool of Light Industry Science and Engineering, Beijing Technology and Business University, Beijing, China.
Meng LiSchool of Light Industry Science and Engineering, Beijing Technology and Business University, Beijing, China. limeng@btbu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Heyndrickxia coagulans is a probiotic strain combining features of lactic acid bacteria and spore-forming bacilli. Its extracellular metabolites (postbiotics), including bacteriocins, organic acids, and short peptides, have gained increasing interest in skincare due to their antibacterial, anti-inflammatory, and antioxidant activities. In this study, Staphylococcus aureus was selected as a model pathogen to evaluate the antibacterial efficacy of H. coagulans metabolites using Oxford cup diffusion and minimum inhibitory concentration (MIC) assays. A 0.5 mg/mL sample produced a 12 mm inhibition zone, and the MIC against S. aureus was determined to be 400 µg/mL. Biofilm assays showed that all tested concentrations inhibited biofilm formation by more than 50% relative to the untreated control. Mechanistic investigations-including bacterial growth curve analysis, membrane permeability assays, and metabolic enzyme activity evaluation-demonstrated that these metabolites disrupted multiple physiological functions of S. aureus, exhibiting antibacterial performance approaching that of mild standard antimicrobials. Overall, this study highlights the potential of H. coagulans metabolites as safe and natural agents for skin health, providing a mechanistic foundation for developing functional skincare products aimed at preventing and controlling skin infections.

Indexed as

Anti-Bacterial AgentsStaphylococcus aureusBacteriocinsBiofilmsMicrobial Sensitivity TestsProbioticsAnti-Bacterial AgentsBacteriocinsAntibacterial activityBiofilmHeyndrickxia coagulansOxidative stressPostbioticsProbiotic metabolites

Identifiers

PMID41556987

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.