EVADR lncRNA Mitigates Neonatal Hypoxic-Ischemic Brain Injury via the miR-145→WNT/β-Catenin Axis and Exhibits Biomarker Potential.

Sen Lu, Mingbin Bao, Junting Hu

Abstract read

In one paragraph

Article in Neurochemical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

3 authors.

Sen LuDepartment of Critical Care Medicine, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, 610072, Chengdu, China.

Mingbin BaoDepartment of Neurosurgery, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, 610072, Chengdu, China.

Junting HuDepartment of Neurosurgery, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, 610072, Chengdu, China. hujunting@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Perinatal hypoxic-ischemic injury (HI) upregulated an endogenous retrovirus-derived lncRNA, EVADR, via HIF-1α/NF-κB. EVADR bound and repressed miR-145, thereby activating WNT/β-catenin signaling. Binding specificity was confirmed by biotin-miRNA pull-down and mutant-seed luciferase reporters. Genetic (si-CTNNB1/si-WNT3A) and pharmacologic (XAV939/CHIR99021) cross-validation demonstrated pathway necessity and rescue. EVADR gain-of-function reduced neuronal death and inflammation and improved behavioral outcomes following HI. Circulating EVADR levels in plasma/CSF correlated with injury severity; ROC analyses indicated diagnostic potential alone and combined with S100B/NSE. These data support EVADR-miR-145→WNT/β-catenin as a mechanistic axis with translational relevance.

Indexed as

beta CateninHypoxia-Ischemia, BrainMicroRNAsRNA, Long NoncodingAnimalsAnimals, NewbornBiomarkersHumansWnt Signaling Pathwaybeta CateninBiomarkersMicroRNAsRNA, Long NoncodingEVADRGene regulationHypoxia-ischemia (HI)Long non-coding RNA (lncRNA)MicroRNA (miRNA)Neonatal brain injuryNeuroinflammationNeuronal survivalNeuroprotectionWNT signaling pathway

Identifiers

PMID41557190

DOI10.1002/wnan.1853

What Socratic holds

Textmetadata

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.