Evidence map›Paper›PMID 41557249›Full record

ArticleNeurochemical research2026

Metabolic Alterations Induced by a Seizure-Causing Sodium Channel Mutation and their Partial Normalization by Dietary α-Linolenic Acid in Drosophila.

Karina Kruth, Junko Kasuya, Victoria Hand, Atulya Iyengar, Toshihiro Kitamoto

Abstract read
In one paragraph

Article in Neurochemical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Karina KruthDepartment of Ophthalmology and Visual Sciences, Carver College of Medicine, University of Iowa, 3107 Medical Education and Research Facility, 375 Newton Road, Iowa City, IA, 52242, USA.ORCID http://orcid.org/0000-0003-2494-0745
Junko KasuyaDepartment of Anesthesia, Carver College of Medicine, University of Iowa, 1-316 Bowen Science Building, 51 Newton Road, Iowa City, IA, 52242, USA.ORCID http://orcid.org/0009-0002-9266-2679
Victoria HandDepartment of Biological Sciences, University of Alabama, 2328 Science and Engineering Center, 300 Hackberry Lane, Tuscaloosa, AL, 35487, USA.ORCID http://orcid.org/0009-0009-3444-0665
Atulya IyengarDepartment of Biological Sciences, University of Alabama, 2328 Science and Engineering Center, 300 Hackberry Lane, Tuscaloosa, AL, 35487, USA.ORCID http://orcid.org/0000-0001-7697-191X
Toshihiro KitamotoDepartment of Anesthesia, Carver College of Medicine, University of Iowa, 1-316 Bowen Science Building, 51 Newton Road, Iowa City, IA, 52242, USA. toshi-kitamoto@uiowa.edu.ORCID http://orcid.org/0000-0003-0863-8466

Funding

Roles of hemocytes and bioactive lipids in the modulation of neuronal excitability and seizure behavior in Drosophila voltage-gated sodium channel mutantsR21NS127364 · NINDS · UNIVERSITY OF IOWA · PI KITAMOTO, TOSHIHIRO · 2022 to 2023
$425k
NIH HHS R21NS127364NINDS NIH HHS R21 NS127364
6 · The paper itself

Abstract

Epilepsy is increasingly recognized as a disorder with prominent metabolic disturbances, but how defined epilepsy-causing mutations reshape metabolism under controlled genetic and environmental conditions remains poorly understood. Here, we used the Drosophila melanogaster gain-of-function voltage-gated sodium channel (VGSC) mutant para

Indexed as

alpha-Linolenic AcidMutationSeizuresSodium ChannelsVoltage-Gated Sodium ChannelsAnimalsDrosophila melanogasterFemalealpha-Linolenic AcidSodium ChannelsVoltage-Gated Sodium ChannelsDietary supplementationDrosophilaEpilepsyMetabolomicsϖ-3 polyunsaturated fatty acid

Identifiers

PMID41557249
PMCPMC12819498

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.