Evidence map›Paper›PMID 41557791›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Dynamic regulation of receptor-modulated endothelial NADPH oxidases.

Markus Waldeck-Weiermair, Apabrita A Das, Taylor A Covington, Jennifer L Meitzler, James H Doroshow, Junyi Duan, Yick W Fong, Jonas Kaynert, Shambhu Yadav, Tanoy Dutta and 3 more

Erratum issuedAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Markus Waldeck-WeiermairHeart and Vascular Institute, Mass General Brigham, Boston, MA 02115.
Apabrita A DasHeart and Vascular Institute, Mass General Brigham, Boston, MA 02115.
Taylor A CovingtonHeart and Vascular Institute, Mass General Brigham, Boston, MA 02115.
Jennifer L MeitzlerCenter for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892.ORCID 0000-0001-9798-2124
James H DoroshowCenter for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892.ORCID 0000-0002-4463-1790
Junyi DuanHeart and Vascular Institute, Mass General Brigham, Boston, MA 02115.
Yick W FongHeart and Vascular Institute, Mass General Brigham, Boston, MA 02115.
Jonas KaynertHeart and Vascular Institute, Mass General Brigham, Boston, MA 02115.
Shambhu YadavHeart and Vascular Institute, Mass General Brigham, Boston, MA 02115.ORCID 0000-0002-0622-1854
Tanoy DuttaHeart and Vascular Institute, Mass General Brigham, Boston, MA 02115.
Fotios SpyropoulosHeart and Vascular Institute, Mass General Brigham, Boston, MA 02115.
Arvind K PandeyHeart and Vascular Institute, Mass General Brigham, Boston, MA 02115.ORCID 0000-0001-7890-4665
Thomas MichelHeart and Vascular Institute, Mass General Brigham, Boston, MA 02115.ORCID 0000-0003-1193-9841

Funding

Chemogenetic Neurovascular Oxidative Stress: Neurodegeneration and Cardiac RemodelingR01NS131182 · NINDS · BRIGHAM AND WOMEN'S HOSPITAL · PI Thomas Michel · 2024 to 2026
$2.3M
Hydrogen peroxide in endothelial function and dysfunctionR01HL152173 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI MICHEL, THOMAS · 2021 to 2024
$2.2M
Oxidative Stress and Mitochondrial Dysfunction in Chemogenetic Heart FailureK08HL168240 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI Fotios Spyropoulos · 2023 to 2026
$735k
Overcoming epigenetic barriers to somatic cell reprogramming by the XPC DNA repair complexR01GM152463 · NIGMS · BRIGHAM AND WOMEN'S HOSPITAL · PI FONG, YICK WAH · 2024 to 2025
$716k
HHS | National Institutes of Health (NIH) K08HL168240-01HHS | National Institutes of Health (NIH) R01HL152173HHS | National Institutes of Health (NIH) R01NS131182NHLBI NIH HHS K08 HL168240NHLBI NIH HHS R01 HL152173NIGMS NIH HHS R01 GM152463NINDS NIH HHS R01 NS131182
6 · The paper itself

Abstract

The stable reactive oxygen species (ROS) hydrogen peroxide (H

Indexed as

Endothelial CellsEndothelium, VascularNADPH Oxidase 2NADPH Oxidase 4NADPH OxidasesAnimalsEndoplasmic ReticulumHumansHydrogen PeroxideOxidation-ReductionReactive Oxygen SpeciesSignal TransductionVascular Endothelial Growth Factor AHydrogen PeroxideNADPH Oxidase 2NADPH Oxidase 4NADPH OxidasesNOX4 protein, humanReactive Oxygen SpeciesVascular Endothelial Growth Factor Aendothelial cell signalinghydrogen peroxideNADPH oxidase

Identifiers

PMID41557791
PMCPMC12846790

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.