Evidence map›Paper›PMID 41557803›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

A neural circuit basis for reward-induced suppression of fear generalization and enhancement of fear extinction.

Yong Sang Jo, Mi-Seon Kong, Ekayana Sethi, Gyeong Hee Pyeon, Larry S Zweifel

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yong Sang Jo *School of Psychology, Korea University, Seoul 02841, Republic of Korea.ORCID 0000-0002-7716-0964
Mi-Seon Kong *Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA 98105.
Ekayana SethiDepartment of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA 98105.
Gyeong Hee PyeonSchool of Psychology, Korea University, Seoul 02841, Republic of Korea.ORCID 0000-0003-4013-3206
Larry S ZweifelDepartment of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA 98105.ORCID 0000-0003-3465-5331

Funding

Isolation of brain reward circuits using peptidergic systemsR01DA044315 · NIDA · UNIVERSITY OF WASHINGTON · PI LARRY S ZWEIFEL · 2018 to 2026
$3.5M
Appetitive and aversive state interactions in the central amygdala during learning and memoryR01MH135538 · NIMH · UNIVERSITY OF WASHINGTON · PI LARRY S ZWEIFEL · 2024 to 2026
$1.7M
Orchestrating state-dependent modulation of motivations in central amygdala CRF neuronsF32MH127801 · NIMH · UNIVERSITY OF WASHINGTON · PI KONG, MI-SEON · 2022 to 2024
$226k
HHS | NIH | National Institute of Mental Health (NIMH) F32MH127801HHS | NIH | National Institute of Mental Health (NIMH) R01MH135538HHS | NIH | NIDA | Intramural Research Program (IRP) R01DA044315NIMH NIH HHS R01 MH135538
6 · The paper itself

Abstract

How positive and negative affective stimuli interact in the brain to influence behavioral outcomes remains poorly understood. Here, we show that recall of a positively valenced reward-associated cue (reward-conditioned stimulus, CS

Indexed as

Extinction, PsychologicalFearRewardAnimalsCentral Amygdaloid NucleusConditioning, ClassicalCuesDopamineMaleMiceMice, Inbred C57BLDopamineamygdaladopamineextinctionfearreward

Identifiers

PMID41557803
PMCPMC12846832

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.