ArticleJournal of the American Chemical Society2026
A Ratiometric pH Sensor for Gram-Positive and Gram-Negative Bacteria.
Article in Journal of the American Chemical Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Activatable NIR-II photoacoustic probes for cancer imaging and imaging-guided therapy.Bioactive materials · 2026Review
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4 authors.
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Abstract
Fluctuating environments can lead to phenotypic heterogeneity within a monoclonal bacterial population, especially in response to antibiotics or the human immune system. Methods are required to analyze the physiology of single cells to understand how individual cells interact with their environment and adapt to pH stress. We report a ratiometric, fluorescent probe to sense cytoplasmic pH in bacteria. Our probes are based on hemicyanine dyes and are taken up into both Gram-positive and Gram-negative bacteria. The probes are selective under a broad range of biologically relevant conditions. The response to pH changes is reversible and rapid, allowing for the real-time tracking of pH fluctuations. The sensing of these probes was tuned to allow for monitoring fluctuations around neutrality and biologically relevant acidifications. These probes were validated for cytoplasmic pH sensing in
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