Evidence map›Paper›PMID 41559010›Full record

ReviewPharmacology research & perspectives2026

Advances in Therapeutic Antibody Discovery and Development Targeting G Protein-Coupled Receptors.

Catherine J Hutchings, Serbülent Ünsal, Mathieu Rappas, Matthew Barnes, Maria Waldhoer, Ben Holland, Martin Culka

Abstract readReview
In one paragraph

Review in Pharmacology research & perspectives, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Catherine J HutchingsIndependent Consultant, Hertfordshire, UK.ORCID https://orcid.org/0009-0004-6806-9554
Serbülent ÜnsalAntiverse, sbarc|spark, Cardiff, UK.
Mathieu RappasNxera Pharma UK Ltd, Cambridge, UK.
Matthew BarnesNxera Pharma UK Ltd, Cambridge, UK.
Maria WaldhoerIkherma Consulting Ltd, Hitchin, Hertfordshire, UK.
Ben HollandAntiverse, sbarc|spark, Cardiff, UK.
Martin CulkaAntiverse, sbarc|spark, Cardiff, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

G protein-coupled receptors (GPCRs) are integral to numerous biological processes and are associated with various diseases across all therapeutic areas. Consequently, GPCRs present substantial potential for antibody-based therapies. This review offers an overview of the therapeutic GPCR-antibody target landscape and examines the diversity within current therapeutic programs at different stages of the research and development pipeline. The progression of the GPCR-antibody pipeline demonstrates ongoing maturation, reflecting advancements that have addressed several longstanding technical challenges. Additionally, we discuss the rapid expansion of artificial intelligence and machine learning platforms designed to accelerate antibody discovery and clinical development, providing specific examples of their application to GPCRs.

Indexed as

AntibodiesAntibodies, MonoclonalDrug DiscoveryReceptors, G-Protein-CoupledAnimalsArtificial IntelligenceHumansMachine LearningAntibodiesAntibodies, MonoclonalReceptors, G-Protein-Coupled

Identifiers

PMID41559010
PMCPMC12819051

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.