Evidence map›Paper›PMID 41559055›Full record

ArticleNature communications2026

Endothelin-3 and T-type Ca

Nicolas R Chevalier, Fanny Gayda, Nadège Bondurand, Ze Chi Chan, Thierry Savy, Monique Frain, Amira El Merhie, Lenuta Canta, Monica Dicu, Isabelle Le Parco and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Nicolas R ChevalierLaboratoire Matière et Systèmes Complexes, Université Paris Cité, CNRS UMR 7057, 10 rue Alice Domon et Léonie Duquet, Paris, France. nicolas.chevalier@u-paris.fr.ORCID http://orcid.org/0000-0002-9713-1511
Fanny GaydaLaboratory of Genetics of Developmental Disorders, Imagine Institute, INSERM UMR 1163, Université Paris Cité, 24 Boulevard du Montparnasse, Paris, France.
Nadège BondurandLaboratory of Genetics of Developmental Disorders, Imagine Institute, INSERM UMR 1163, Université Paris Cité, 24 Boulevard du Montparnasse, Paris, France.
Ze Chi ChanLaboratoire Matière et Systèmes Complexes, Université Paris Cité, CNRS UMR 7057, 10 rue Alice Domon et Léonie Duquet, Paris, France.
Thierry SavyLaboratoire Matière et Systèmes Complexes, Université Paris Cité, CNRS UMR 7057, 10 rue Alice Domon et Léonie Duquet, Paris, France.ORCID http://orcid.org/0000-0001-5970-3817
Monique FrainLaboratoire Matière et Systèmes Complexes, Université Paris Cité, CNRS UMR 7057, 10 rue Alice Domon et Léonie Duquet, Paris, France.
Amira El MerhieLaboratoire Matière et Systèmes Complexes, Université Paris Cité, CNRS UMR 7057, 10 rue Alice Domon et Léonie Duquet, Paris, France.ORCID http://orcid.org/0000-0001-6580-9677
Lenuta CantaUNIIVO, 1 cour du Havre, Paris, France.
Monica DicuUNIIVO, 1 cour du Havre, Paris, France.
Isabelle Le ParcoInstitut Jacques Monod, Université Paris Cité, CNRS, Paris, France.
Léna ZigLaboratoire Matière et Systèmes Complexes, Université Paris Cité, CNRS UMR 7057, 10 rue Alice Domon et Léonie Duquet, Paris, France.

Funding

Agence Nationale de la Recherche (French National Research Agency) ANR-10-INBS-04Agence Nationale de la Recherche (French National Research Agency) ANR-11-LABX-0071Agence Nationale de la Recherche (French National Research Agency) ANR-19-CE30-0016-01
6 · The paper itself

Abstract

Enteric neural crest cells (ENCCs) colonize the gut during embryogenesis and migration defects give rise to Hirschsprung disease (HD). Mutations in GDNF/RET and EDN3/EDNRB are known to be causal in HD. Here, we show that migrating ENCCs in mice exhibit endogenous EDN3/EDNRB-gated calcium activity, mediated by chloride channels, T-type Ca

Indexed as

CalciumCalcium Channels, T-TypeCell MovementEndothelin-3Enteric Nervous SystemNeural CrestAnimalsHirschsprung DiseaseMiceMutationReceptor, Endothelin BCacna1h protein, mouseCalciumCalcium Channels, T-TypeEDNRB protein, mouseEndothelin-3Receptor, Endothelin B

Identifiers

PMID41559055
PMCPMC12876838

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.