SynthesisNature human behaviour2026
Population attributable fractions of a wide range of peripheral diseases for the burden of dementia.
Synthesis in Nature human behaviour, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Global, regional, and national burden of dementia attributable to mood disorders: a comparative risk assessment study.The journal of prevention of Alzheimer's disease · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
Abstract
Growing evidence suggests that peripheral diseases serve as risk factors for dementia, but the population-level burden of dementia associated with various peripheral diseases has remained unknown. Here, by conducting a systematic review and Bayesian meta-analyses to estimate the relative risks of 26 peripheral diseases across 9 systems with dementia, including 202 articles searched from the PubMed until 6 September 2024, we identified 16 peripheral diseases as associated with increased risk of dementia. With the relative risks estimated from meta-analyses, prevalences extracted from the Global Burden of Disease Study, and communalities among these 16 peripheral diseases derived from the UK Biobank, we analysed the population attributable fractions (PAFs) of these 16 peripheral diseases for dementia, stratified by sex, age, sociodemographic index level, world region and country, and trends from 1990 to 2021. Globally, these peripheral diseases collectively were related to a combined PAF of 33.18% (95% confidence interval (CI) 16.80-48.43) of dementia burden, corresponding to 18.8 million prevalent cases. The leading ten PAF contributors were periodontal diseases (6.10%, 95% CI 0.95-10.28), cirrhosis and other chronic liver diseases (5.51%, 95% CI 1.77-8.86), age-related and other hearing loss (4.70%, 95% CI 3.51-6.06), blindness and vision loss (4.30%, 95% CI 3.43-5.05), type 2 diabetes mellitus (3.80%, 95% CI 3.06-4.53), chronic kidney disease (2.74%, 95% CI 1.53-4.02), osteoarthritis (2.26%, 95% CI 0.41-4.12), stroke (1.01%, 95% CI 0.86-1.17), ischaemic heart disease (0.97%, 95% CI 0.69-1.29) and chronic obstructive pulmonary disease (0.92%, 95% CI 0.34-1.54). This study revealed that a series of peripheral diseases were associated with increased risk of dementia and collectively were related to about one-third of the global dementia burden, highlighting the need for targeted public health strategies.
Indexed as
Identifiers
41559195What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.