Evidence mapPaperPMID 41559445Full record

ArticleNature metabolism2026

Distinct sympathetic projections to brown fat regulate thermogenesis and glucose tolerance.

Daniele Neri, Seoeun Lee, Alexis M Fohn, Xinhong Chen, Dominique Bozec, Alexandre J Lafond, Natalie R Lopatinsky, Lucas Castro E Souza, Gawri Mohanan Nair, Angela M Ramos-Lobo and 6 more

Abstract read
In one paragraph

Article in Nature metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Overview of the DREADDs chemogenetics and the patent landscape of their actuators.Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2026
    Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Daniele NeriNaomi Berrie Diabetes Center, Division of Preventive Medicine, Columbia University Irving Medical Center, New York, NY, USA.ORCID http://orcid.org/0000-0003-4376-6324
Seoeun LeeNaomi Berrie Diabetes Center, Division of Preventive Medicine, Columbia University Irving Medical Center, New York, NY, USA.
Alexis M FohnNaomi Berrie Diabetes Center, Division of Preventive Medicine, Columbia University Irving Medical Center, New York, NY, USA.
Xinhong ChenCalifornia Institute of Technology, Pasadena, CA, USA.
Dominique BozecNaomi Berrie Diabetes Center, Division of Preventive Medicine, Columbia University Irving Medical Center, New York, NY, USA.
Alexandre J LafondNaomi Berrie Diabetes Center, Division of Preventive Medicine, Columbia University Irving Medical Center, New York, NY, USA.
Natalie R LopatinskyNaomi Berrie Diabetes Center, Division of Preventive Medicine, Columbia University Irving Medical Center, New York, NY, USA.
Lucas Castro E SouzaNaomi Berrie Diabetes Center, Division of Preventive Medicine, Columbia University Irving Medical Center, New York, NY, USA.ORCID http://orcid.org/0000-0003-1512-3030
Gawri Mohanan NairNaomi Berrie Diabetes Center, Division of Preventive Medicine, Columbia University Irving Medical Center, New York, NY, USA.
Angela M Ramos-LoboNaomi Berrie Diabetes Center, Division of Preventive Medicine, Columbia University Irving Medical Center, New York, NY, USA.
Markus HeineUniversity Medical Center Hamburg Eppendorf, Hamburg, Germany.
Anna WorthmannUniversity Medical Center Hamburg Eppendorf, Hamburg, Germany.
Joerg HeerenUniversity Medical Center Hamburg Eppendorf, Hamburg, Germany.ORCID http://orcid.org/0000-0002-5647-1034
Vidhu V ThakerDepartment of Pediatrics, Columbia University Irving Medical Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-3537-2782
Viviana GradinaruCalifornia Institute of Technology, Pasadena, CA, USA.ORCID http://orcid.org/0000-0001-5868-348X
Lori M ZeltserNaomi Berrie Diabetes Center, Division of Preventive Medicine, Columbia University Irving Medical Center, New York, NY, USA. lz146@cumc.columbia.edu.ORCID http://orcid.org/0000-0002-4330-6240

Funding

Tumor Biology and Microenvironment ProgramP30CA013696 · COLUMBIA UNIV NEW YORK MORNINGSIDE · 1985 to 2025
$22.9M
Clinical and Translational Science AwardUL1TR001873 · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2025 to 2025
$10.0M
Translational Biomarker Analytical Core (TBAC)P30DK063608 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2003 to 2025
$8.5M
Transcriptomic CoreP01AG032959 · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2025 to 2025
$3.4M
NUTRITIONT32DK007647 · COLUMBIA UNIV NEW YORK MORNINGSIDE · 1990 to 2025
$1.7M
Vascular sympathetic neurons in brown adipose tissue and systemic metabolismR01DK140355 · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2025 to 2025
$801k
NCATS NIH HHS UL1 TR001873NCI NIH HHS P30 CA013696NIA NIH HHS P01 AG032959NIDDK NIH HHS R01 DK125094NIDDK NIH HHS R01 DK140355NIDDK NIH HHS R56 DK140355NIDDK NIH HHS T32 DK007647NIH HHS OT2 OD023853NIH HHS S10 OD032321NIH HHS S10 OD034377U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) P30DK063608U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) R01DK125094U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) R56DK140355U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) P01AG032959U.S. Department of Health & Human Services | NIH | NIH Office of the Director (OD) OT2OD023853U.S. Department of Health & Human Services | NIH | NIH Office of the Director (OD) S10OD034377
6 · The paper itself

Abstract

Brown adipose tissue (BAT) contributes to thermoregulation and glucose metabolism, but how these functions are coordinated remains unclear. While thermogenesis in the activated BAT typically coincides with increased blood flow and glucose uptake

Indexed as

Adipose Tissue, BrownGlucoseSympathetic Nervous SystemThermogenesisAnimalsMaleMiceMice, Inbred C57BLGlucose

Identifiers

PMID41559445
PMCPMC12945688

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.