Evidence map›Paper›PMID 41559452›Full record

ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2026

Epigenetic treatment of synaptic and behavioral deficits in Dyrk1a-mutant mice.

Chih-Hung Lin, Mingjun Yu, Prachetas Jai Patel, Pei Li, Zhen Yan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Chih-Hung LinDepartment of Physiology and Biophysics, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY, USA.ORCID http://orcid.org/0009-0004-0663-9021
Mingjun YuDepartment of Physiology and Biophysics, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY, USA.ORCID http://orcid.org/0009-0008-3447-0154
Prachetas Jai PatelDepartment of Physiology and Biophysics, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY, USA.
Pei LiDepartment of Physiology and Biophysics, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY, USA.
Zhen YanDepartment of Physiology and Biophysics, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY, USA. zhenyan@buffalo.edu.ORCID http://orcid.org/0000-0002-3519-9596

Funding

U.S. Department of Health & Human Services | National Institutes of Health (NIH) NS127728
6 · The paper itself

Abstract

Haploinsufficiency of Dyrk1a, which encodes the dual-specificity tyrosine phosphorylation regulated kinase 1A (DYRK1A), has been causally linked to autism. Here we examined transcriptomic, electrophysiological and behavioral alterations in mice carrying a loss-of-function mutation of Dyrk1a (Dyrk

Indexed as

Autistic DisorderEpigenesis, GeneticPrefrontal CortexProtein Serine-Threonine KinasesProtein-Tyrosine KinasesSynapsesSynaptic TransmissionAnimalsAnxietyDyrk KinasesFemaleHistone DemethylasesMaleMiceMice, TransgenicMutationDyrk KinasesHistone DemethylasesKDM1a protein, mouseProtein Serine-Threonine KinasesProtein-Tyrosine Kinases

Identifiers

PMID41559452
PMCPMC13291241

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.