ArticleJournal of materials science. Materials in medicine2026
Template-assisted synthesis of pH-responsive hollow mesoporous silica nanocarriers: the role of engineered pores and surface characteristics.
Article in Journal of materials science. Materials in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Hollow silica nanoparticles (HSNPs), characterized by a hollow interior enclosed within a solid mesoporous silica shell, offer several advantages, including low density, high surface area, excellent adsorption capacity, and biocompatibility, making them highly attractive for diverse applications in fields such as food, construction, electronics, imaging, and nanomedicine. To investigate the largely unexplored role of the hollow interior and surface functionality in the design of smart nanocarriers, we propose a facile, green-chemistry-based approach for the synthesis of HSNPs, utilizing polystyrene nanoparticles (64 ± 11 nm in diameter) as sacrificial templates. An ultrathin mesoporous silica shell, 10-12 nm in thickness, is conformally deposited through the controlled hydrolysis of a Si precursor, yielding a nanocarrier system that enables the high adsorption of macromolecules with a pH-sensitive desorption profile. Comprehensive analytical techniques reveal that the method of template removal significantly influences both the interior and exterior pore structures. Notably, calcination produces HSNPs with a higher specific surface area ( > 195 m² g⁻¹), a larger average pore diameter ( ~ 20 nm), and an ink-bottle-like mesoporous structure. It is shown that these structural differences, combined with tailored surface functionalities, critically modulate the triggering response of the nanocarrier. To demonstrate functionality, doxorubicin hydrochloride (DOX) was employed as a model drug. A pH-responsive desorption behavior, releasing the biomacromolecule four times faster at pH=4.5 than at pH=7.4, is presented. This finding underscores the impact of surface chemistry and pore architecture on the adsorption and desorption kinetics of macromolecules. The results of this study pave the way for the rational design of stimuli-responsive ceramic nanocarriers with enhanced adsorption efficiency and precise, controlled desorption capabilities.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.