Observational studyMedicine2026
Association between elevated circulating FABP4 levels and postoperative prognosis in osteoarthritis patients undergoing joint arthroplasty: A prospective cohort study.
Observational study in Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
This study aimed to investigate the potential role of fatty acid binding protein 4 (FABP4) in predicting prognosis after total hip arthroplasty (THA) or total knee arthroplasty (TKA). A total of 400 patients undergoing TKA or THA and 100 healthy controls were included. Patients were categorized into a complication group if local postoperative complications occurred within 90 days post-surgery; otherwise, they were classified as the no complications group. The demographic and clinical data of the 2 groups were compared, and the clinical characteristics and risk factors of local postoperative complications within 90 days of TKA/THA were evaluated. Plasma FABP4 concentrations were measured using an ELISA kit. FABP4 concentration (odds ratio [OR] = 1.521, 95% confidence interval [CI] = 1.190-1.944, P = .001), American Society of Anesthesiologists physical status classification (OR = 0.064, 95% CI = 0.005-0.811, P = .034), and estimated intraoperative blood loss (OR = 1.070, 95% CI = 1.008-1.135, P = .027) were identified as significant predictors of 90-day local postoperative complications. Elevated levels of FABP4 are frequently observed in patients experiencing local postoperative complications within 90 days following TKA/THA. FABP4 concentration, American Society of Anesthesiologists class, and estimated intraoperative blood loss are risk factors for the development of this complications, although further validation in advanced clinical trials is required.
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