Evidence map›Paper›PMID 41560718›Full record

ArticlePhotoacoustics2026

Vascular graph network for ovarian lesion classification using optical-resolution photoacoustic microscopy.

Yixiao Lin, Lukai Wang, Ian S Hagemann, Lindsay M Kuroki, Brooke E Sanders, Andrea R Hagemann, Cary Siegel, Matthew A Powell, Quing Zhu

Abstract read
In one paragraph

Article in Photoacoustics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yixiao LinBiomedical Engineering Department, Washington University in St Louis, USA.
Lukai WangBiomedical Engineering Department, Washington University in St Louis, USA.
Ian S HagemannDepartment of Obstetrics & Gynecology, School of Medicine, Washington University in St Louis, USA.
Lindsay M KurokiDepartment of Obstetrics & Gynecology, School of Medicine, Washington University in St Louis, USA.
Brooke E SandersDepartment of Obstetrics & Gynecology, School of Medicine, Washington University in St Louis, USA.
Andrea R HagemannDepartment of Obstetrics & Gynecology, School of Medicine, Washington University in St Louis, USA.
Cary SiegelMallinckrodt Institute of Radiology, School of Medicine, Washington University in St Louis, USA.
Matthew A PowellDepartment of Obstetrics & Gynecology, School of Medicine, Washington University in St Louis, USA.
Quing ZhuBiomedical Engineering Department, Washington University in St Louis, USA.

Funding

Coregistered Photoacoustic and Ultrasound Imaging for Ovarian Cancer Diagnosis and Risk ManagementR01CA237664 · NCI · WASHINGTON UNIVERSITY · PI POWELL, MATTHEW A, SIEGEL, CARY L · 2020 to 2024
$2.6M
Predicting neoadjuvant treatment response of locally advanced rectal cancer using co-registered endo-rectal photoacoustic and ultrasound imagingR01EB034398 · NIBIB · WASHINGTON UNIVERSITY · PI William Chapman, Quing Zhu · 2023 to 2026
$1.7M
NCI NIH HHS R01 CA237664NIBIB NIH HHS R01 EB034398
6 · The paper itself

Abstract

Diagnosing ovarian lesions is challenging because of their heterogeneous clinical presentations. Some benign ovarian conditions, such as endometriosis, can have features that mimic cancer. We use optical-resolution photoacoustic microscopy (OR-PAM) to study the differences in ovarian vasculature between cancer and various benign conditions. In this study, we converted OR-PAM vascular data into vascular graphs augmented with physical vascular properties. From 94 ovarian specimens, a custom vascular graph network (VGN) was developed to classify each graph as either normal ovary, one of three benign pathologies, or cancer. We demonstrated for the first time that, by leveraging the intrinsic similarity between vascular networks and graph constructs, VGN provides stable predictions from sampling surface areas as small as 3 mm× 0.12 mm. In diagnosing cancer, VGN achieved 79.5 % accuracy and an area under the receiver operating characteristic curve (AUC) of 0.877. Overall, VGN achieved a five-class classification accuracy of 73.4 %.

Indexed as

Deep learningGraph neural networkMultiparametric imagingOptical-resolution photoacoustic microscopyOvarian cancer

Identifiers

PMID41560718
PMCPMC12813362

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.