Evidence mapPaperPMID 41560732Full record

ArticleFrontiers in pharmacology2025

Harnessing red grape pomace extract for sustainable broad-spectrum photoprotection in a reconstructed human epidermis model.

Antonella Smeriglio, Marta Mangano, Mariarosaria Ingegneri, Annarita La Neve, Chiara Brenna, Luca Mastracci, Francesco Merlino, Giancarlo Tonon, Diego Bosco, Domenico Trombetta

Abstract read
In one paragraph

Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Antonella SmeriglioDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno d'Alcontres, Messina, Italy.
Marta ManganoDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno d'Alcontres, Messina, Italy.
Mariarosaria IngegneriDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno d'Alcontres, Messina, Italy.
Annarita La NeveDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno d'Alcontres, Messina, Italy.
Chiara BrennaPrigen srl, Milan, Italy.
Luca MastracciPathology Unit, Department of Surgical Sciences and Integrated Diagnostics (DISC), University of Genova, Genova, Italy.
Francesco MerlinoUniverlab srl, Milan, Italy.
Giancarlo TononPrigen srl, Milan, Italy.
Diego BoscoItalbiotec s.r.l., Milan, Italy.
Domenico TrombettaDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno d'Alcontres, Messina, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Red grape pomace, a major by-product of the winemaking industry, represents a sustainable source of bioactive polyphenols with high nutraceutical and cosmetic potential. In this study, a standardized grape pomace extract (GPE) was developed from quality-controlled dried pomace, compliant with European Pharmacopoeia requirements for heavy metals, microbiological purity, and residual moisture. Phytochemical profiling by LC-DAD-ESI-MS/MS revealed a complex composition dominated by anthocyanins-primarily malvidin-3-

Indexed as

anti-inflammatory activityantioxidant activitycircular economydermocosmetic formulationgrape pomace extractphotoprotectionpolyphenolsreconstructed human epidermis

Identifiers

PMID41560732
PMCPMC12812985

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.