Evidence map›Paper›PMID 41560797›Full record

ArticleMaterials today. Bio2026

Targeting single-cell multiomics-identified vascular impairment:

Feiping Xia, Xiaoyin Li, Xinbei Wen, Bolin Chen, Guanghong Wu, Xiaolong Ye, Yongjian Sun, Xiaoxu Liu, Lei Fan, Yingbin Wang and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Feiping XiaThe First Clinical Medical College, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing, 210023, Jiangsu, China.
Xiaoyin LiDivision of Orthopaedic Surgery, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Xinbei WenSouthern Medical University, Guangzhou, 510515, Guangdong, China.
Bolin ChenSouthern Medical University, Guangzhou, 510515, Guangdong, China.
Guanghong WuSouthern Medical University, Guangzhou, 510515, Guangdong, China.
Xiaolong YeDepartment of Gastrointestinal Surgery, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510630, Guangdong Province, China.
Yongjian SunDepartment of Pediatric Orthopedics, Center for Orthopedic Surgery, The Third Affiliated Hospital of Southern Medical University, Guangzhou, 510515, China.
Xiaoxu LiuDepartment of Anesthesiology, Nanfang Hospital, Southern Medical University, Guangdong Provincial Key Laboratory of Precision Anesthesia and Perioperative Organ Protection, Guangzhou, 510515, Guangdong, China.
Lei FanDivision of Orthopaedic Surgery, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Yingbin WangDepartment of Anesthesiology, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, 730030, Gansu Province, China.
Shuofei YangDepartment of Vascular Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Pujian Road 160, Shanghai, 200127, China.
Ping YeDepartment of Orthopaedics, Shanghai Changzheng Hospital, Second Affiliated Hospital of Naval Medical University, Shanghai, 200003, China.
Hong DingDepartment of Anesthesiology, Nanfang Hospital, Southern Medical University, Guangdong Provincial Key Laboratory of Precision Anesthesia and Perioperative Organ Protection, Guangzhou, 510515, Guangdong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetic skin wounds, a severe complication affecting over 18.6 million people globally, are characterized by high amputation and mortality rates. However, the cellular heterogeneity of diabetic wounds and the specific molecular mechanisms underlying their impaired healing remain unclear. Furthermore, treatment strategies based on medicinal plants targeting these pathological mechanisms are lacking. This study explored diabetic wound pathogenesis using single-cell RNA sequencing (scRNA-seq), revealing a 52 % reduction in vascular endothelial cells (ECs) and a decreased abundance of proliferative ECs in diabetic wound tissues, which contributed to impaired vascular repair. Network pharmacology and RT-qPCR identified E-selectin (SELE) as the key target of

Indexed as

AdhesiveAngiogenesisDiabetic woundExtracellular vesiclesNetwork pharmacologyPanax notoginsengscRNA-seq

Identifiers

PMID41560797
PMCPMC12813230

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.