Evidence map›Paper›PMID 41560800›Full record

ArticleMaterials today. Bio2026

Kartogenin-loaded chitosan composite scaffold with cartilage-mimetic microstructure for layered osteochondral repair and cartilage phenotype maintenance.

Hengyu Liu, Hongqing Qiao, Rudong Li, Wenbo Yang, Xingchen Guo, Yuhang Wang, Nan Mei, Jincheng Wang, Fei Chang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hengyu LiuDepartment of Orthopedic Surgery, The Second Hospital of Jilin University, Changchun 130041, PR China.
Hongqing QiaoDepartment of Orthopedic Surgery, The Second Hospital of Jilin University, Changchun 130041, PR China.
Rudong LiDepartment of Gastrointestinal Nutrition and Hernia Surgery, The Second Hospital of Jilin University, Changchun 130041, PR China.
Wenbo YangDepartment of Orthopedic Surgery, The Second Hospital of Jilin University, Changchun 130041, PR China.
Xingchen GuoDepartment of Orthopedic Surgery, The Second Hospital of Jilin University, Changchun 130041, PR China.
Yuhang WangDepartment of Orthopedic Surgery, The Second Hospital of Jilin University, Changchun 130041, PR China.
Nan MeiDepartment of Orthopaedic Surgery, Nara Medical University, Kashihara 634-8521, Japan.
Jincheng WangDepartment of Orthopedic Surgery, The Second Hospital of Jilin University, Changchun 130041, PR China.
Fei ChangDepartment of Orthopedic Surgery, The Second Hospital of Jilin University, Changchun 130041, PR China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Osteochondral defects represent a formidable clinical challenge due to their distinctive stratified architecture and limited intrinsic healing capacity. However, conventional tissue engineering scaffolds exhibit significant limitations in replicating the gradient properties of native osteochondral tissue while maintaining chondrogenic phenotypes. This study presents a novel bio-customized gradient scaffold CSK@G inspired by natural osteochondral architecture, developed through strategic material composition control and graduated porosity design techniques, for integrated repair of osteochondral defects. Through precise biomimetic design, the scaffold successfully recapitulates the spatial heterogeneity of native tissue by accurately mimicking five anatomically distinct layers-superficial cartilage, middle cartilage, deep cartilage, calcified cartilage, and subchondral bone. Additionally, Kartogenin (KGN)-loaded Chitosan (CS) hydrogels are strategically incorporated within cartilaginous zones to facilitate stem cell homing and create optimal cellular microenvironments that provide region-specific biochemical cues for enhanced chondrogenic differentiation. Comprehensive experimental results, both

Indexed as

3D printingCartilage microstructureChitosanGradient structureLayered repairOsteochondral

Identifiers

PMID41560800
PMCPMC12813363

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.