Evidence map›Paper›PMID 41560812›Full record

ArticleMaterials today. Bio2026

miR-19b-3p engineered adipose-derived stem cell exosomes attenuate acute liver failure via promoting tissue repair and microenvironment remodeling.

Baitong Wu, Jiuxing Feng, Xi Wang, Jingyi Guo, Lanyue Sheng, Jian Wang, Jiaqi Xu, Jie Zhou, Guangming Wang, Yi Wen and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Baitong WuEast Hospital, Stem Cell Research Center, School of Medicine, Tongji University, Shanghai, 200120, China.
Jiuxing FengShanghai Key Laboratory of Medical Epigenetics, Institutes of Biomedical Sciences, Fudan University, Shanghai, 200032, China.
Xi WangDepartment of Hepatology Infection, Guizhou Provincial People's Hospital, Guizhou, 550000, China.
Jingyi GuoEast Hospital, Stem Cell Research Center, School of Medicine, Tongji University, Shanghai, 200120, China.
Lanyue ShengEast Hospital, Stem Cell Research Center, School of Medicine, Tongji University, Shanghai, 200120, China.
Jian WangEast Hospital, Stem Cell Research Center, School of Medicine, Tongji University, Shanghai, 200120, China.
Jiaqi XuEast Hospital, Stem Cell Research Center, School of Medicine, Tongji University, Shanghai, 200120, China.
Jie ZhouDepartment of Hematology, Tongji Hospital of Tongji University, Shanghai, 200065, China.
Guangming WangDepartment of Hematology, Tongji Hospital of Tongji University, Shanghai, 200065, China.
Yi WenEast Hospital, Stem Cell Research Center, School of Medicine, Tongji University, Shanghai, 200120, China.
Jiaxin LiuEast Hospital, Stem Cell Research Center, School of Medicine, Tongji University, Shanghai, 200120, China.
Shu ZhaoDepartment of Anesthesiology and Perioperative medicine, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, 200434, China.
Danjing YangEast Hospital, Stem Cell Research Center, School of Medicine, Tongji University, Shanghai, 200120, China.
Yinpeng JinShanghai Public Health Clinical Center, Fudan University, Shanghai, 201508, China.
Qingchun FuShanghai Public Health Clinical Center, Fudan University, Shanghai, 201508, China.
Jun XuEast Hospital, Stem Cell Research Center, School of Medicine, Tongji University, Shanghai, 200120, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute liver failure (ALF) is a life-threatening clinical syndrome, characterized by rapid hepatocyte injury and deteriorating hepatic microenvironment. To date, there is still no effective clinical treatment for ALF. Adipose-derived stem cells (ADSCs) have been proven to be an ideal seed-cell in tissue engineering and regenerative medicine through ADSCs-derived exosomes (ADSC-EXO) by paracrine effect. Herein, we presented an ADSC-EXO based therapeutic strategy that could facilitate microenvironment reconstruction and tissue repairing simultaneously in ALF. We demonstrated that miR-19b-3p exhibited remarkable anti-inflammation and anti-oxidation effect. Functionalized exosomes miR-19-EXO administration elevated survival rates from 25 % to 75 %, concurrently reversing liver function, promoting histoarchitectural integrity, and ameliorating inflammatory infiltration

Indexed as

Acute liver failureADSCsExosomesMicroenvironment remodelingNanomedicine

Identifiers

PMID41560812
PMCPMC12813244

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.