ReviewMaterials today. Bio2026
Recent advances in biomaterials for bone regeneration: Bridging innovation and clinical translation.
Review in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- Smart and stimuli-responsive hydrogels for controlled exosome delivery in bone tissue engineering: from passive carriers to intelligent therapeutic platforms.Cell and tissue banking · 2026Review
- From bone replacement to regeneration. A biomaterials started journey.Materials today. Bio · 2026Review
- Editorial for Special Issue "Osteoclastogenesis and Osteogenesis: Physiological and Molecular Responses to Xenobiotics and Biomaterials".Current issues in molecular biology · 2026Article
- Osteoinductive and Biocompatibility Assessment of a 3D-Printed Polymeric-Hydroxyapatite Composite Interference Screw.Polymers · 2026Article
- Cotton-Type Nanofiber Guided Pathway Engineering Enables Rapid Tissue Integration and Accelerated Bone Regeneration in Mineral Powder-Based Bone Grafts.Journal of functional biomaterials · 2026Article
- Histological Study of a Novel 3D-Printed Hydroxyapatite/PLGA Bone Graft in the Regeneration of Critical-Sized Long Bone Defects.Bioengineering (Basel, Switzerland) · 2026Article
- A review on β-cyclodextrin-based self-healable supramolecular systems: mechanisms and biomedical applications.RSC advances · 2026Review
- Article
- Biofunctionalization of mineralized collagen with platelet-rich plasma enhances osteogenesis in critical-sized bone defects.Frontiers in bioengineering and biotechnology · 2026Article
- Biomaterials in personalized drug delivery: innovations, challenges, and future directions.PeerJ · 2026Review
- MgFe-Layered Double Hydroxide-Reinforced Injectable GelMA Hydrogels Promote Calvarial Bone Regeneration with IL-10RA-JAK1-STAT3-Associated Osteoimmunomodulation.International journal of nanomedicine · 2026Article
- Injectable Mn-Icariin-functionalized silk fibroin/PEG hydrogels restore redox homeostasis and reprogram osteogenic-angiogenic coupling for diabetic bone regeneration.Regenerative biomaterials · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bone regeneration presents an enduring clinical barrier, particularly with the projected rise in osteoporotic fractures exceeding 6 million annually by 2050. Autografts, allografts, and xenografts remain foundational in bone repair due to their inherent osteogenic, osteoconductive, and osteoinductive capacities. However, issues such as donor site morbidity, immunogenicity, limited graft availability, and pathogen transmission risks limit their applicability. In response, recent developments in biomaterials, including ion-doped bioceramics, bioactive glass-polymer composites, and stem cell-functionalized hydrogels, aim to replicate the hierarchical structure and biochemical microenvironment of native bone. This review surveys advancements in scaffold materials over the past five years, evaluating their physicochemical properties, immune modulation potential, and clinical readiness within the context of bone tissue engineering (BTE). Specific attention is given to strategies for selecting appropriate biomaterials based on clinical needs, considering their physical and biological properties, as well as their respective advantages and limitations. Despite this progress, clinical translation remains limited; only a few engineered scaffolds have achieved regulatory approval for routine use. To accelerate adoption, efforts must focus on scalable fabrication, quantitative immune profiling, and scaffold degradation monitoring to bridge preclinical performance with clinical efficacy.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.