ArticleJournal of human reproductive sciences
Luteinizing Hormone β-subunit Gene Polymorphisms and Androgen Levels are Less Predictive of Ovarian Response in Polycystic Ovary Syndrome
Article in Journal of human reproductive sciences. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Genetic polymorphisms in the luteinizing hormone (LH) β-subunit gene have been associated with responses to controlled ovarian hyperstimulation (COH) in Aim: The aim of this study was to investigate the clinical significance of LH β-subunit single-nucleotide polymorphism (SNP) (rs1800447 and rs34349826), levels of testosterone, sex hormone-binding globulin (SHBG) and free testosterone index in predicting COH response in polycystic ovary syndrome (PCOS) women. Settings and Design: This nested case-control study enlisted 122 women with PCOS in the Morula IVF Jakarta Clinic, Jakarta, Indonesia. Materials and Methods: The selection of cases and controls was in the ratio of 1:2. Blood samples were taken on day 2 or 3 of menstrual cycle. Sanger sequencing was utilised to genotype the LH β-subunit genes (rs1800447 and rs34349826). Levels of testosterone and SHBG were measured to calculate the free testosterone index. Women were retrospectively grouped as hyporesponders (<8 oocytes) or normo/hyperresponders (≥8 oocytes) according to the number of retrieved oocytes. Statistical Analysis Used: SPSS Software version 21.0 (IBM Corp., USA). Independent Results: A unique automatic transmission (AT) variant in both rs1800447 and rs34349826 LH β-subunit was discovered, which has yet been reported previously. Notably, the proportion of heterozygous LH β genotypes (AT and AG) in both rs1800447 and rs34349826 was similar between hyporesponder and normo/hyperresponder groups ( Conclusion: LH β gene SNPs (rs1800447 and rs34349826), testosterone level, SHBG level and free testosterone index were not significantly correlated and less effective clinical indicators for COH response in normoandrogenic PCOS women.
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