SynthesisFrontiers in endocrinology2025
Bariatric surgery as a treatment of polycystic ovary syndrome: a systematic review and meta-analysis.
Synthesis in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Maternal Metabolic Dysfunction and Uteroplacental Adaptation in Polyendocrine Metabolic Ovarian Syndrome Pregnancy.Reproductive sciences (Thousand Oaks, Calif.) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among females of reproductive age, and the majority are obese/overweight. PCOS management, including lifestyle and drugs, is limited by unsustainability and side effects. Bariatric surgery (BS) is promising in addressing hyperandrogenism and pregnancy outcomes. We aimed to assess the impact of bariatric surgery on PCOS components. Methods: We systematically searched PubMed/MEDLINE, Google Scholar, Cochrane Library, and Web of Science during July and August 2025, articles from inception up to August 2025 were included. The keywords used were BS, sleeve gastrectomy, gastric bypass, gastric banding, menstrual irregularities, free testosterone, total testosterone, hirsutism, SHBG, lutenizing hormone, antimullarian hormone (AMH), follicle-stimulating hormone, and pre-term deliveries. 648 articles were eligible, 35 full texts were reviewed, and 27 were included in the final meta-analysis. Results: Bariatric surgery reduced menstrual irregularities and hirsutism, with odds ratios of 27.68, 95% CI, 9.83-78.00, and 6.61, 95% CI, 0.97-47.07, respectively. In addition, total testosterone, free testosterone, AMH, and LH were reduced, SD, -19.95, 95% CI, -28.53-11.38, SD, 2.40, 95% CI, 1.30.53-3.51, SD, 1.66, 95% CI, 0.17-3.14, and SD, 2.21, 95% CI, 1.73-2.69 respectively, while SHBG were increased. No effects were observed regarding FSH, birth weight, gestational age, and pre-term delivery. Conclusion: BS reduced menstrual irregularities, hirsutism, total and free testosterone, AMH, and LH and increased SHBG. No significant differences were evident regarding other outcomes. Larger controlled trials investigating the long-term effects and the mechanism of action of BS on pregnancy outcomes, metabolic, and reproductive hormones are needed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.