Evidence map›Paper›PMID 41561107›Full record

ArticleERJ open research2026

Mucociliary and cough clearance in primary ciliary dyskinesia as affected by mutations in

Lawrence E Ostrowski, Sara Abu-Nasser, Kirby L Zeman, Margaret W Leigh, Maimoona A Zariwala, Kenneth N Olivier, Thomas W Ferkol, Corinne N Taylor, Agathe S Ceppe, Michael R Knowles and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ERJ open research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Unrecognized ciliary motility disorders in neutrophilic severe asthma exacerbations.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Lawrence E OstrowskiDepartment of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID https://orcid.org/0000-0002-7558-6603
Sara Abu-NasserDepartment of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Kirby L ZemanCenter for Environmental Medicine, Asthma, and Lung Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Margaret W LeighDepartment of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Maimoona A ZariwalaDepartment of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID https://orcid.org/0000-0003-1619-1393
Kenneth N OlivierDepartment of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Thomas W FerkolDepartment of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Corinne N TaylorDepartment of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Agathe S CeppeMarsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Michael R KnowlesMarsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
William D BennettCenter for Environmental Medicine, Asthma, and Lung Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID https://orcid.org/0000-0002-6054-0768

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Primary ciliary dyskinesia (PCD) is a rare disease caused by mutations in >50 genes that impair the function of motile cilia. The clinical phenotype is heterogeneous and recent studies have begun to investigate genotype-phenotype relationships to better understand disease pathogenesis and develop improved treatments. The major cause of morbidity and mortality among individuals with PCD is the lack of mucociliary clearance (MCC) that results in chronic respiratory infections and leads to bronchiectasis. Here we examine the relationship between MCC and genotype in two groups of PCD individuals; one with mutations in a gene ( Methods: Patients with known pathogenic variants in Results: Neither Conclusions: The results confirm impaired MCC in people with PCD of both genotypes. However, in this small cohort, the results suggest cough clearance may differ between these two genotypes.

Identifiers

PMID41561107
PMCPMC12813685

What Socratic holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.