Evidence map›Paper›PMID 41561386›Full record

ArticleiScience2026

Single-cell landscape of immune cells in multiple autoimmune diseases.

Lin Zhu, Wujianan Sun, Kun Chen, Zitian Liu, Meifang Tang, Chen Jiang, Yu Shi, Qian Liu, Wen Zhang, Junyu Wang and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Lin ZhuDepartment of Rheumatology and Immunology, The First Affiliated Hospital of USTC, State Key Laboratory of Eye Health, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230021, China.
Wujianan SunDepartment of Rheumatology and Immunology, The First Affiliated Hospital of USTC, State Key Laboratory of Eye Health, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230021, China.
Kun ChenDepartment of Rheumatology and Immunology, The First Affiliated Hospital of USTC, State Key Laboratory of Eye Health, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230021, China.
Zitian LiuDepartment of Rheumatology and Immunology, The First Affiliated Hospital of USTC, State Key Laboratory of Eye Health, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230021, China.
Meifang TangDepartment of Rheumatology and Immunology, The First Affiliated Hospital of USTC, State Key Laboratory of Eye Health, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230021, China.
Chen JiangDepartment of Rheumatology and Immunology, The First Affiliated Hospital of USTC, State Key Laboratory of Eye Health, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230021, China.
Yu ShiDepartment of Rheumatology and Immunology, The First Affiliated Hospital of USTC, State Key Laboratory of Eye Health, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230021, China.
Qian LiuDepartment of Rheumatology and Immunology, The First Affiliated Hospital of USTC, State Key Laboratory of Eye Health, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230021, China.
Wen ZhangDepartment of Rheumatology and Immunology, The First Affiliated Hospital of USTC, State Key Laboratory of Eye Health, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230021, China.
Junyu WangDepartment of Rheumatology and Immunology, The First Affiliated Hospital of USTC, State Key Laboratory of Eye Health, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230021, China.
Ao ZhengDepartment of Rheumatology and Immunology, The First Affiliated Hospital of USTC, State Key Laboratory of Eye Health, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230021, China.
Jun LinDepartment of Rheumatology and Immunology, The First Affiliated Hospital of USTC, State Key Laboratory of Eye Health, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230021, China.
Guosheng WangDepartment of Rheumatology and Immunology, The First Affiliated Hospital of USTC, State Key Laboratory of Eye Health, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230021, China.
Xiaomei LiDepartment of Rheumatology and Immunology, The First Affiliated Hospital of USTC, State Key Laboratory of Eye Health, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230021, China.
Xu LiuDepartment of Rheumatology and Immunology, The First Affiliated Hospital of USTC, State Key Laboratory of Eye Health, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230021, China.
Kun QuDepartment of Rheumatology and Immunology, The First Affiliated Hospital of USTC, State Key Laboratory of Eye Health, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230021, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autoimmune pathologies arise from dysregulated immune activation, yet conserved molecular programs across autoimmune contexts remain incompletely characterized. Here, we analyzed integrative single-cell RNA sequencing data of over 1.3 million cells from 239 samples spanning six autoimmune diseases, revealing disease-specific and cell type-specific transcriptional programs. Systematic immune profiling identified 41 functionally annotated gene clusters (GCs) with cross-disease activation. We identified a cytotoxic

Indexed as

BioinformaticsGenomicsImmunology

Identifiers

PMID41561386
PMCPMC12814431

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.