ArticleFrontiers in oncology2025
The Identification of LA-tumor associated macrophages in immune modulation via amyloid-beta precursor protein/CD74 signal pathway in gastric cancer: a predictive module and machine learning.
Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Article
- YAP1 induces hepatocellular carcinoma via DNA demethylation rather than by canonical driver gene mutations.Communications biology · 2026Article
- Integrative Multiomics Analysis Reveals Tumor-Associated Macrophage Heterogeneity and a Prognostic Signature in Gastric Cancer.Human mutation · 2026Article
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Authors and funding
5 authors.
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Abstract
Background: Tumor-associated macrophages (TAMs) play a critical role in cancer immune microenvironment, modulating immune evasion. The prognostic role of TAMs gives insights into the immune landscape and therapeutic targets in gastric cancer (GC). Methods: GC microenvironment was analyzed via single-cell and bulk RNA-seq data from public databases. TAM subtypes were then identified via dimensionality reduction and annotation under quality control. TAM differentiation and function were evaluated by pseudo-time analysis, cell communication, molecular docking, and key gene enrichment. A predictive model based on LA-TAM was established. Amyloid-β precursor protein (APP) expression level and its effect on macrophage programmed death-1 (PD-1) expression was validated Results: In GC microenvironment, epithelial cells and fibroblasts were downregulated, while B cells, CD8 Conclusion: LA-TAM plays a key role in immune suppression and metabolic regulation in GC. Its key genes form a high-precision prognosis model, and endothelial cell-expressed APP may promote immune evasion by enhancing macrophage PD-1 expression, suggesting a potential target for immunotherapy.
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