ArticleFuture science OA2026
The P7 peptide antagonizes bFGF-induced malignant behaviors of ovarian cancer by inhibiting MEK/ERK signaling pathway.
Article in Future science OA, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundOvarian cancer (OC) is a highly invasive malignancy with poor prognosis, underscoring the need for novel therapeutic strategies. Basic fibroblast growth factor (bFGF) promotes OC progression by activating the MEK/ERK signaling pathway, enhancing tumor cell proliferation, migration, and invasion. P7 peptide is a novel peptide with potential antitumor effects, though its mechanism of action remains unclear. This study investigates whether P7 peptide inhibits bFGF-induced OC progression via suppression of the MEK/ERK pathway.
methodsHuman OC Anglne cells were treated with varying concentrations of bFGF and P7 peptide. Cell proliferation was measured using CCK-8 assays, while RT-PCR and Western blot analyses evaluated the expression of uPA, MMP2, and E-cadherin, along with MEK/ERK pathway activation. Cell migration and invasion were assessed via wound healing and Transwell assays.
resultsbFGF (30 ng/mL, 48 h) significantly enhanced cell proliferation and invasive behavior, alongside upregulation of uPA and MMP2 and reduced E-cadherin expression. P7 peptide (16 μM, 48 h) effectively reversed these effects and inhibited MEK/ERK phosphorylation.
conclusionThese findings suggest that P7 peptide suppresses bFGF-mediated OC progression by targeting the MEK/ERK pathway, supporting its potential as a novel therapeutic agent in OC.
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