Evidence map›Paper›PMID 41562914›Full record

ArticleMedical sciences (Basel, Switzerland)2026

Preoperative Prognostic Score for Patients with Intrahepatic Cholangiocarcinoma Undergoing Curative-Intent Resection.

Jarin Chindaprasirt, Thanachai Sanlung, Piyakarn Watcharenwong, Vasin Thanasukarn, Apiwat Jareanrat, Natcha Khuntikeo, Tharatip Srisuk, Prakasit Sa-Ngiamwibool, Chaiwat Aphivatanasiri, Watcharin Loilome and 2 more

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Article in Medical sciences (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Jarin ChindaprasirtMedical Oncology Program, Department of Medicine Srinagarind Hospital, Khon Kaen University, Khon Kaen 40002, Thailand.ORCID 0000-0002-0401-9812
Thanachai SanlungMedical Oncology Program, Department of Medicine Srinagarind Hospital, Khon Kaen University, Khon Kaen 40002, Thailand.ORCID 0000-0001-8094-3241
Piyakarn WatcharenwongMedical Oncology Program, Department of Medicine Srinagarind Hospital, Khon Kaen University, Khon Kaen 40002, Thailand.
Vasin ThanasukarnCholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen 40002, Thailand.
Apiwat JareanratCholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen 40002, Thailand.
Natcha KhuntikeoCholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen 40002, Thailand.ORCID 0009-0006-6689-2525
Tharatip SrisukCholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen 40002, Thailand.ORCID 0000-0001-7850-2500
Prakasit Sa-NgiamwiboolCholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen 40002, Thailand.
Chaiwat AphivatanasiriCholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen 40002, Thailand.ORCID 0000-0001-9185-4121
Watcharin LoilomeCholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen 40002, Thailand.ORCID 0000-0001-8572-5577
Piya PrajumwongsCholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen 40002, Thailand.
Attapol TitapunCholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen 40002, Thailand.

Funding

This research was funded by the Fundamental Fund of Khon Kaen University, supported by the National Science, Research and Innovation Fund (NSRF), allocated to Dr. Attapol Titapun
6 · The paper itself

Abstract

backgroundPreoperative inflammatory and nutrition-related markers-including the neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), prognostic nutritional index (PNI), and controlling nutritional status (CONUT) score-have shown prognostic relevance in various malignancies. However, their comparative utility in predicting recurrence and survival across clinically relevant subgroups in patients with intrahepatic cholangiocarcinoma (iCCA) undergoing curative-intent resection remains unclear.

methodsThis retrospective study included 213 patients with histologically confirmed iCCA who underwent curative-intent resection between 2015 and 2021. Preoperative NLR, LMR, PNI, and CONUT scores were calculated from laboratory data obtained within one week before resection. Clinicopathological variables, recurrence, and survival outcomes were analyzed using Cox regression and Kaplan-Meier methods.

resultsA preoperative NLR ≥ 2.4 was independently associated with poorer DFS (HR = 1.66,

conclusionsPreoperative NLR was associated with poorer DFS and OS in iCCA patients undergoing curative-intent resection. This association was consistently observed in subgroups with R0 resection and in those who developed recurrence. Meanwhile, the CONUT score showed limited independent significance only among patients with R0 resection who experienced recurrence.

Indexed as

Bile Duct NeoplasmsCholangiocarcinomaAgedFemaleHumansLymphocytesMaleMiddle AgedNeoplasm Recurrence, LocalNeutrophilsNutritional StatusPreoperative PeriodPrognosisRetrospective Studiesdisease-free survivalintrahepatic cholangiocarcinomaoverall survivalpreoperative scoreprognosis

Identifiers

PMID41562914
PMCPMC12821497

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.