ArticleEnvironmental science & technology2026
Challenging Additivity: Comparing Predicted and Observed AhR Activity of Polycyclic Aromatic Compound (PAC) Mixtures Containing Active and Inactive Constituents.
Article in Environmental science & technology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Class-based cumulative risk assessment approaches have been applied to high-priority environmental contaminants such as polycyclic aromatic compounds (PACs), yet uncertainties remain in their application. In this study, we evaluated the influence of inactive chemicals on mixture modeling outcomes and explored strategies for predicting the aryl hydrocarbon receptor (AhR)-mediated toxicity of PAC mixtures. Using an in vitro AhR reporter gene assay, we tested seven defined mixtures composed of six active and seven inactive PACs. Observed concentration-response curves were compared to predictions from three established mixture models, concentration addition (CA), independent action (IA), and generalized concentration addition (GCA), using both effective concentration eliciting 10% response (EC10) and benchmark concentration (BMC
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