Evidence map›Paper›PMID 41563294›Full record

ReviewSao Paulo medical journal = Revista paulista de medicina2026

Postoperative delirium in patients with cancer: a narrative review of major risk factors.

Alessandra Bittencourt de Oliveira, Adriana Mayumi Handa, Eduardo Sakai, Arthur Caus de Morais, Michael Madeira de la Cruz Quezada, Jorge Kiyoshi Mitsunaga Junior, Assaiah Moreira Marrazzo da Costa Portugal, Eduardo Henrique Giroud Joaquim, Giane Nakamura

Abstract readReview
In one paragraph

Review in Sao Paulo medical journal = Revista paulista de medicina, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Alessandra Bittencourt de OliveiraPhysician, Departamento de Anestesiologia, A.C.Camargo Cancer Center, São Paulo (SP), Brazil.ORCID 0009-0004-9686-0829
Adriana Mayumi HandaPhysician, Departamento de Anestesiologia, A.C.Camargo Cancer Center, São Paulo (SP), Brazil.ORCID 0009-0009-0652-9830
Eduardo SakaiPhysician, Departamento de Anestesiologia, A.C.Camargo Cancer Center, São Paulo (SP), Brazil.ORCID 0009-0007-2392-9698
Arthur Caus de MoraisPhysician, Departamento de Anestesiologia, A.C.Camargo Cancer Center, São Paulo (SP), Brazil.ORCID 0000-0001-8786-0406
Michael Madeira de la Cruz QuezadaPhysician, Departamento de Anestesiologia, A.C.Camargo Cancer Center, São Paulo (SP), Brazil.ORCID 0000-0001-9754-0916
Jorge Kiyoshi Mitsunaga JuniorPhysician, Departamento de Anestesiologia, A.C.Camargo Cancer Center, São Paulo (SP), Brazil.ORCID 0000-0003-0261-4359
Assaiah Moreira Marrazzo da Costa PortugalPhysician, Departamento de Anestesiologia, A.C.Camargo Cancer Center, São Paulo (SP), Brazil.ORCID 0009-0004-8400-6203
Eduardo Henrique Giroud JoaquimProfessor, Departamento de Anestesiologia, A.C.Camargo Cancer Center, São Paulo (SP), Brazil.ORCID 0009-0009-3754-9324
Giane NakamuraProfessor, Departamento de Anestesiologia, A.C.Camargo Cancer Center, São Paulo (SP), Brazil.ORCID 0000-0003-0227-0875

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPostoperative delirium (POD) is a severe complication and the most frequent adverse event in older patients, particularly those with cancer. With the increase in the older surgical population and cancer diagnoses, the incidence of POD is expected to increase.

objectivesTo identify and evaluate major risk factors for POD in patients with cancer. DESIGN AND

settingNarrative review conducted at the A.C.Camargo Cancer Center in São Paulo, Brazil.

methodsPubMed, LILACS, and Embase database searches were conducted using relevant keywords from June 2023, to September 2024. We identified 279 studies; after screening and applying the eligibility criteria, 49 studies were included in the analysis. RESULTS AND DISCUSSION: POD risk factors in patients with cancer are associated with inflammation and the cumulative burden of intensive therapeutic modalities. These factors can be categorized into three domains: directly related to cancer, indirectly related to cancer, and preexisting predisposing factors. Among these factors, age is important. Additional relevant contributors include frailty, cognitive impairment, sarcopenia, pain, anxiety, and depression. A complex interaction exists between these factors that renders POD management in patients with cancer challenging; however, the impact of each factor remains unclear.

conclusionsMultiple overlapping risk factors often contribute to POD development in patients with cancer. Age is a significant risk factor, as reported in the literature. Other relevant factors have been described; however, the relative contribution of each factor to the etiology of POD remains unclear. Further research is required to address this knowledge gap.

Indexed as

DeliriumNeoplasmsPostoperative ComplicationsAge FactorsHumansRisk Factors

Identifiers

PMID41563294
PMCPMC12810936

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.