Evidence map›Paper›PMID 41563530›Full record

ArticlePurinergic signalling2026

Spinal P2X

Pedro Segura-Chama, Lucio Antonio Ramos-Chávez, Nashiely Yañez-Recendis, Francisco Pellicer, Martha León-Olea, Angélica Almanza, Francisco Mercado

Abstract read
In one paragraph

Article in Purinergic signalling, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Pedro Segura-ChamaLaboratorio de Fisiología Celular, Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Calzada México-Xochimilco 101, Col. San Lorenzo Huipulco, Alcaldía Tlalpan, Ciudad de México, CP, 14370, México. segurapd@gmail.com.
Lucio Antonio Ramos-ChávezLaboratorio de Neuromorfología Funcional, Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría Ramón de La Fuente Muñiz, Ciudad de México, México.
Nashiely Yañez-RecendisLaboratorio de Fisiología Celular, Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Calzada México-Xochimilco 101, Col. San Lorenzo Huipulco, Alcaldía Tlalpan, Ciudad de México, CP, 14370, México.
Francisco PellicerLaboratorio de Neurofisiología Integrativa, Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría Ramón de La Fuente Muñiz, Ciudad de México, México.
Martha León-OleaLaboratorio de Neuromorfología Funcional, Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría Ramón de La Fuente Muñiz, Ciudad de México, México.
Angélica AlmanzaLaboratorio de Fisiología Celular, Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Calzada México-Xochimilco 101, Col. San Lorenzo Huipulco, Alcaldía Tlalpan, Ciudad de México, CP, 14370, México.
Francisco MercadoLaboratorio de Fisiología Celular, Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Calzada México-Xochimilco 101, Col. San Lorenzo Huipulco, Alcaldía Tlalpan, Ciudad de México, CP, 14370, México. fmercado@inprf.gob.mx.

Funding

Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Ciudad de México, México NC24196.0Secretaría de Ciencia, Humanidades, Tecnología e Innovación, México CF-2023-G-1190Secretaría de Ciencia, Humanidades, Tecnología e Innovación, México CF-2023-I-667
6 · The paper itself

Abstract

Allodynia to mechanical stimuli is one of the most prevalent symptoms in paclitaxel-treated cancer patients. Paclitaxel induces ATP release from nerve terminals; thus, peripheral primary sensory neurons can be sensitized by ATP, as a large subgroup expresses purinergic P2X

Indexed as

Antineoplastic Agents, PhytogenicHyperalgesiaPaclitaxelPurinergic P2X Receptor AntagonistsReceptors, Purinergic P2X3Spinal CordAnimalsFemaleMaleRatsRats, Sprague-DawleyAntineoplastic Agents, PhytogenicPaclitaxelPurinergic P2X Receptor AntagonistsReceptors, Purinergic P2X3AllodyniaAnalgesiaPaclitaxelPainPurinergic receptors

Identifiers

PMID41563530
PMCPMC12824064

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.