Evidence map›Paper›PMID 41564132›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Platelet-derived growth factor receptor alpha regulates fetal testis differentiation via an ERK-CREB axis.

Shu-Yun Li, Satoko Matsuyama, Sarah Whiteside, Xiaowei Gu, Jonah Cool, Blanche Capel, Tony DeFalco

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Shu-Yun Li *Reproductive Sciences Center, Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229.
Satoko Matsuyama *Reproductive Sciences Center, Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229.ORCID 0000-0002-2460-0313
Sarah WhitesideReproductive Sciences Center, Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229.
Xiaowei GuReproductive Sciences Center, Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229.
Jonah CoolDepartment of Cell Biology, Duke University Medical Center, Durham, NC 27710.
Blanche CapelDepartment of Cell Biology, Duke University Medical Center, Durham, NC 27710.ORCID 0000-0002-6587-0969
Tony DeFalcoReproductive Sciences Center, Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229.ORCID 0000-0003-4133-7040

Funding

OPPOSING PATHWAYS IN MAMMALIAN SEX DETERMINATIONR01HD039963 · NICHD · DUKE UNIVERSITY · PI CAPEL, BLANCHE · 2001 to 2025
$4.7M
Exploring vascular-mesenchymal interactions in the stem cell nicheR01HD094698 · NICHD · CINCINNATI CHILDRENS HOSP MED CTR · PI DEFALCO, TONY J. · 2018 to 2022
$1.6M
Cincinnati Children's Hospital Medical Center (CCHMC) N/AHHS | NIH (NIH) R01HD039963HHS | NIH (NIH) R01HD094698NICHD NIH HHS R01 HD039963NICHD NIH HHS R01 HD094698
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Cell DifferentiationCyclic AMP Response Element-Binding ProteinExtracellular Signal-Regulated MAP KinasesMAP Kinase Signaling SystemReceptor, Platelet-Derived Growth Factor alphaTestisAnimalsCell MovementLeydig CellsMaleMiceMice, KnockoutOrganogenesisSignal TransductionCreb1 protein, mouseCyclic AMP Response Element-Binding ProteinExtracellular Signal-Regulated MAP KinasesReceptor, Platelet-Derived Growth Factor alphaERKLeydig cellorganogenesissteroidogenesistestis

Identifiers

PMID41564132
PMCPMC12849703

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.