Improvements in bone quality by parathyroid hormone treatment are enhanced in the Nmp4 knockout mouse model.

Runkang Chen, Bowen Wang, Samuel J Stephen, Joseph P Bidwell, Deepak Vashishth

Abstract read

In one paragraph

Article in Bone, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Runkang ChenDepartment of Biomedical Engineering, Rensselaer Polytechnic Institute (RPI), Troy, NY, USA; Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY, USA.

Bowen WangShirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY, USA; RPI - Icahn School of Medicine, Mount Sinai Center for Engineering and Precision Medicine, New York, NY, USA.

Samuel J StephenDepartment of Biomedical Engineering, Rensselaer Polytechnic Institute (RPI), Troy, NY, USA; Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY, USA; Department of Orthopedic Surgery, University of California, San Francisco, San Francisco, CA, USA.

Joseph P BidwellDepartment of Anatomy, Cell Biology & Physiology, Indiana University School of Medicine, Indianapolis, IN, USA.

Deepak VashishthDepartment of Biomedical Engineering, Rensselaer Polytechnic Institute (RPI), Troy, NY, USA; Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY, USA; RPI - Icahn School of Medicine, Mount Sinai Center for Engineering and Precision Medicine, New York, NY, USA. Electronic address: vashid@rpi.edu.

Funding

Effects of Advanced Glycation Endproducts on Type 2 Diabetic and Fragility FracturesR01AG075654 · RENSSELAER POLYTECHNIC INSTITUTE · 2025 to 2025

$551k

NIAMS NIH HHS R01 AR073739NIA NIH HHS R01 AG075654NIH HHS S10 OD025049

6 · The paper itself

Abstract

Osteoporosis is linked to increased bone fragility. Unlike anti-resorptive therapies, the analogue of parathyroid hormone, PTH 1-34, is an FDA-approved therapeutic for osteoporosis that enhances bone formation. However, as PTH treatment potency declines over time, it is necessary to investigate the mechanisms involved in this attenuation to reinforce its long-term efficacy. This need has led to investigations into the transcription factor nuclear matrix protein 4 (Nmp4), in which PTH treatment of mice globally lacking Nmp4 (Nmp4

Indexed as

Bone and BonesNuclear Matrix-Associated ProteinsParathyroid HormoneTranscription FactorsAnimalsBiomechanical PhenomenaBone DensityCortical BoneDisease Models, AnimalFemaleFemurMiceMice, KnockoutX-Ray MicrotomographyNuclear Matrix-Associated ProteinsParathyroid HormoneTranscription FactorsZfp384 protein, mouseBone extracellular matrix compositionsBone qualityFracture mechanicsNuclear matrix protein 4OsteoporosisParathyroid hormone

Identifiers

PMID41565170

DOI10.1016/j.bone.2026.117800

PMCPMC12861313

What Socratic holds

Textmetadata

LicenceTDM

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.