Evidence map›Paper›PMID 41565469›Full record

ArticleGenome research2026

Degrees of convergent evolution in rodent adaptations to arid environments.

Domitille Chalopin, Carine Rey, Jeremy Ganofsky, Juliana Blin, Pascale Chevret, Marion Mouginot, Laurent Guéguen, Bastien Boussau, Sophie Pantalacci, Marie Sémon

Abstract read
In one paragraph

Article in Genome research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. bioRxiv : the preprint server for biology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Domitille Chalopin *Laboratoire de Biologie et Modélisation de la Cellule, CNRS UMR 5239, Université Claude Bernard Lyon 1, Ecole Normale Supérieure de Lyon, Université de Lyon, Lyon 69007, France; domitille.chalopin-fillot@u-bordeaux.fr sophie.pantalacci@ens-lyon.fr marie.semon@ens-lyon.fr.ORCID 0000-0003-0588-9630
Carine Rey *Laboratoire de Biologie et Modélisation de la Cellule, CNRS UMR 5239, Université Claude Bernard Lyon 1, Ecole Normale Supérieure de Lyon, Université de Lyon, Lyon 69007, France.ORCID 0000-0003-4871-8110
Jeremy GanofskyLaboratoire de Biologie et Modélisation de la Cellule, CNRS UMR 5239, Université Claude Bernard Lyon 1, Ecole Normale Supérieure de Lyon, Université de Lyon, Lyon 69007, France.
Juliana BlinLaboratoire de Biologie et Modélisation de la Cellule, CNRS UMR 5239, Université Claude Bernard Lyon 1, Ecole Normale Supérieure de Lyon, Université de Lyon, Lyon 69007, France.
Pascale ChevretLaboratoire de Biométrie et Biologie Evolutive, CNRS UMR 5558, Université Claude Bernard Lyon 1, Villeurbanne 69622, France.ORCID 0000-0002-4186-875X
Marion MouginotLaboratoire de Biologie et Modélisation de la Cellule, CNRS UMR 5239, Université Claude Bernard Lyon 1, Ecole Normale Supérieure de Lyon, Université de Lyon, Lyon 69007, France.
Laurent GuéguenLaboratoire de Biométrie et Biologie Evolutive, CNRS UMR 5558, Université Claude Bernard Lyon 1, Villeurbanne 69622, France.ORCID 0000-0001-7838-791X
Bastien BoussauLaboratoire de Biométrie et Biologie Evolutive, CNRS UMR 5558, Université Claude Bernard Lyon 1, Villeurbanne 69622, France.ORCID 0000-0003-0776-4460
Sophie PantalacciLaboratoire de Biologie et Modélisation de la Cellule, CNRS UMR 5239, Université Claude Bernard Lyon 1, Ecole Normale Supérieure de Lyon, Université de Lyon, Lyon 69007, France; domitille.chalopin-fillot@u-bordeaux.fr sophie.pantalacci@ens-lyon.fr marie.semon@ens-lyon.fr.
Marie SémonLaboratoire de Biologie et Modélisation de la Cellule, CNRS UMR 5239, Université Claude Bernard Lyon 1, Ecole Normale Supérieure de Lyon, Université de Lyon, Lyon 69007, France; domitille.chalopin-fillot@u-bordeaux.fr sophie.pantalacci@ens-lyon.fr marie.semon@ens-lyon.fr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Species adapting to a similar lifestyle may undergo convergent changes in organ structure and cellular function, themselves relying or not on these convergent genetic changes. The extent of genomic convergence is thus debated and may further depend on the interplay between temporal factors, such as species relatedness or the age of the transition. Rodents have repeatedly adapted to life in arid conditions, notably with altered renal morphology and physiology. By analyzing kidney transcriptomes from 33 species, we find convergence at all examined biological levels, from the whole kidney transcriptome down to the coding sequences and expression level of individual genes. Transcriptome-level signatures reflect convergent changes in cell proportions, suggesting convergent structural adaptations of the kidney. A large proportion of genes shows convergent substitutions, but those happened in small subsets of species, showing that there are multiple genetic paths repeatedly taken in a mosaic manner. A similar mosaic signal of convergence is found comparing gene expression in species spanning the

Indexed as

Adaptation, PhysiologicalBiological EvolutionEvolution, MolecularRodentiaAnimalsDesert ClimateGene Expression ProfilingKidneyPhylogenyTranscriptome

Identifiers

PMID41565469
PMCPMC12951959

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.