Evidence map›Paper›PMID 41565507›Full record

ArticlePain management nursing : official journal of the American Society of Pain Management Nurses2026

Pre-implementation Barriers and Facilitators to Integrating Complementary and Integrative Health Interventions into Clinic Workflow: The GRACE Trial, NIH Pragmatic Trials Collaboratory.

Stephanie O Ibemere, Mitchell R Knisely, Ivy Akpotu, Juanita E Darby, Victoria A de Martelly, Ardith Z Doorenbos, Miriam O Ezenwa, Nadine S Matthie, Robert E Molokie, Judith M Schlaeger and 4 more

Abstract read
In one paragraph

Article in Pain management nursing : official journal of the American Society of Pain Management Nurses, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Stephanie O IbemereDuke University, School of Nursing, Durham, NC; Duke University, Global Health Institute, Durham, NC.
Mitchell R KniselyDuke University, School of Nursing, Durham, NC.
Ivy AkpotuUniversity of Illinois Chicago, College of Nursing, Chicago, IL.
Juanita E DarbyUniversity of Illinois Chicago, College of Nursing, Chicago, IL.
Victoria A de MartellyUniversity of Illinois Chicago, College of Nursing, Chicago, IL.
Ardith Z DoorenbosUniversity of Illinois Chicago, College of Nursing, Chicago, IL.
Miriam O EzenwaUniversity of Florida, College of Nursing, Gainesville, FL.
Nadine S MatthieEmory University, Nell Hodgson Woodruff School of Nursing, Atlanta, GA.
Robert E MolokieUniversity of Illinois Chicago, College of Medicine, Chicago, IL; Jesse Brown VA Medical Center, Chicago, IL; University of Illinois Chicago, Retzky College of Pharmacy, Chicago, IL.
Judith M SchlaegerUniversity of Illinois Chicago, College of Nursing, Chicago, IL.
Nirmish ShahDuke University, School of Medicine, Durham, NC.
Diana J WilkieUniversity of Florida, College of Nursing, Gainesville, FL.
C Patrick CarrollJohns Hopkins University, School of Medicine, Baltimore, MD.
Crystal L PatilUniversity of Michigan, School of Nursing, Ann Arbor, MI. Electronic address: clpatil@umich.edu.

Funding

NIH Health Care Systems Research Collaboratory-Coordinating Center (U24)U24AT009676 · NCCIH · DUKE UNIVERSITY · PI LESLEY H CURTIS, Adrian Hernandez · 2017 to 2026
$21.5M
HEAL Collaboratory Resource Coordinating Center (PRISM) (U24): Bioethics SupplementU24AT010961 · NCCIH · DUKE UNIVERSITY · PI CURTIS, LESLEY H, HERNANDEZ, ADRIAN · 2019 to 2021
$6.4M
Hybrid Effectiveness-Implementation Trial of Guided Relaxation and Acupuncture for Chronic Sickle Cell Disease PainUH3AT011265 · NCCIH · UNIVERSITY OF ILLINOIS AT CHICAGO · PI DOORENBOS, ARDITH Z, EZENWA, MIRIAM OMELEBELE · 2021 to 2024
$6.4M
Hybrid Effectiveness-Implementation Trial of Guided Relaxation and Acupuncture for Chronic Sickle Cell Disease PainUG3AT011265 · NCCIH · UNIVERSITY OF ILLINOIS AT CHICAGO · PI DOORENBOS, ARDITH Z, EZENWA, MIRIAM OMELEBELE · 2020 to 2020
$827k
NCCIH NIH HHS U24 AT009676NCCIH NIH HHS U24 AT010961NCCIH NIH HHS UG3 AT011265NCCIH NIH HHS UH3 AT011265
6 · The paper itself

Abstract

backgroundEven though there is clear evidence supporting the use of complementary and integrative health (CIH) interventions for chronic pain, their integration into clinical care is challenging. Thus, the purpose of this study was to understand how the integration of CIH interventions, namely, guided relaxation and acupuncture evaluated in the Hybrid Effectiveness-Implementation Trial of Guided Relaxation and Acupuncture for Chronic Sickle Cell Disease Pain (GRACE Trial), would impact clinic workflow at each study site.

methodsWe conducted a qualitative descriptive study using individual interviews with healthcare providers and staff working at GRACE Trial sites. Interview data were analyzed using modified rapid qualitative analysis.

resultsWe interviewed 13 healthcare providers from three GRACE Trial sites. Two major themes were identified: (1) the variable impact of CIH integration on clinic operations, and (2) the introduction of CIH interventions into clinical practice.

conclusionThis study highlights the importance and value of participatory approaches in integrating CIH interventions into healthcare settings. This study contributes to the CIH literature by addressing chronic pain and informing the identification of strategies to target the multi-layered challenges of integrating evidence-based CIH interventions into practice.

Indexed as

Complementary TherapiesIntegrative MedicineWorkflowAnemia, Sickle CellChronic PainFemaleHumansInterviews as TopicNational Institutes of Health (U.S.)Pain ManagementPragmatic Clinical Trials as TopicQualitative ResearchUnited StatesChronic painComplementary and integrative healthEvidence-based pain managementPain managementSickle cell disease

Identifiers

PMID41565507
PMCPMC13016120

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.