ArticleCommunications medicine2026
Plasma and pericardial fluid metabolomic signatures of patients with ischemic heart disease.
Article in Communications medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Gut microbiota-derived metabolites in cardiovascular disease: mechanisms, disease-specific roles, and translational opportunities.Frontiers in cardiovascular medicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
backgroundIschemic heart disease is the leading cause of global mortality. Despite advances in clinical management, current diagnostic tools do not capture early metabolic disturbances associated with myocardial ischemia. Understanding these alterations may provide new insights into disease mechanisms.
methodsA metabolomic approach based on magnetic resonance spectroscopy is used to characterize the metabolic profile of patients with ischemic heart disease compared with non-ischemic individuals. Plasma and pericardial fluid collected during cardiac surgery are analyzed to investigate both systemic and heart-proximal molecular changes. Small-molecule concentrations are quantified and statistically evaluated to identify metabolic differences associated with ischemia.
resultsHere we show that ischemic heart disease is associated with a distinct metabolic pattern. We observe increased concentrations of 3-hydroxybutyrate in both biological fluids, together with elevated succinate in pericardial fluid, indicating alterations in mitochondrial energy metabolism. Additional changes involve pathways linked to substrate utilization and redox balance.
conclusionsThese findings highlight a metabolic response to myocardial ischemia detectable in both systemic and locally collected fluids. The identified alterations offer a deeper understanding of the biochemical environment associated with ischemic heart disease.
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.