Evidence map›Paper›PMID 41565804›Full record

ArticleNature2026

The transition from monocyte to tissue-resident macrophage requires DHPS.

Gustavo E Carrizo, Pianpian Lin, Seung Hyun Lee, Kevin Shenderov, Camille Blériot, Minsun Cha, Lena Schimmelpfennig, Zhen Shen, Nikki van Teijlingen Bakker, Katarzyna M Grzes and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Gustavo E CarrizoBloomberg-Kimmel Institute for Cancer Immunotherapy, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Pianpian Lin *Bloomberg-Kimmel Institute for Cancer Immunotherapy, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Seung Hyun Lee *Bloomberg-Kimmel Institute for Cancer Immunotherapy, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Kevin ShenderovBloomberg-Kimmel Institute for Cancer Immunotherapy, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Camille BlériotSingapore Immunology Network (SIgN), Agency for Science, Technology and Research, Singapore, Singapore.ORCID 0000-0002-4298-2888
Minsun ChaBloomberg-Kimmel Institute for Cancer Immunotherapy, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Lena SchimmelpfennigMax Planck Institute of Immunobiology and Epigenetics, Freiburg im Breisgau, Germany.
Zhen ShenBloomberg-Kimmel Institute for Cancer Immunotherapy, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0009-0003-9763-5255
Nikki van Teijlingen BakkerMax Planck Institute of Immunobiology and Epigenetics, Freiburg im Breisgau, Germany.
Katarzyna M GrzesBloomberg-Kimmel Institute for Cancer Immunotherapy, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Beth KellyBloomberg-Kimmel Institute for Cancer Immunotherapy, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Niloufar SafiniaDepartment of Inflammation Biology, Institute of Liver Studies, School of Immunology and Microbial Sciences, James Black Centre, King's College London, London, UK.
Kate L ScholeDepartment of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Yaarub MusaMax Planck Institute of Immunobiology and Epigenetics, Freiburg im Breisgau, Germany.
Gerhard MittlerMax Planck Institute of Immunobiology and Epigenetics, Freiburg im Breisgau, Germany.ORCID 0000-0003-2634-0487
Yoh ZenDepartment of Inflammation Biology, Institute of Liver Studies, School of Immunology and Microbial Sciences, James Black Centre, King's College London, London, UK.
Edward J PearceBloomberg-Kimmel Institute for Cancer Immunotherapy, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Florent GinhouxSingapore Immunology Network (SIgN), Agency for Science, Technology and Research, Singapore, Singapore.
David E SaninBloomberg-Kimmel Institute for Cancer Immunotherapy, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0003-0188-7267
Daniel J PulestonBloomberg-Kimmel Institute for Cancer Immunotherapy, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. daniel.puleston@mssm.edu.ORCID 0000-0002-8437-0732
Erika L PearceBloomberg-Kimmel Institute for Cancer Immunotherapy, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. epearce6@jhmi.edu.ORCID 0000-0001-5592-5439

Funding

The Role of the Amino Acid Hypusine in the Maintenance and Function of Tissue-Resident MacrophagesR01AI170599 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Erika L Pearce · 2023 to 2026
$2.1M
Exploring metabolic governance of immune cell form and functionDP2AI177905 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Daniel Puleston · 2023 to 2026
$2.0M
Thyroid Cell Signaling: Targeting Src and BRAFF32CA177282 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI VANDEN BORRE, PIERRE BENOIT · 2013 to 2014
$50k
NCI NIH HHS F32 CA177282NIAID NIH HHS DP2 AI177905NIAID NIH HHS R01 AI170599
6 · The paper itself

Abstract

Tissue-resident macrophages (RTMs) form during embryogenesis, self-renew locally, and regulate tissue homeostasis by clearing dead cells and debris

Indexed as

Cell DifferentiationMacrophagesMonocytesOxidoreductases Acting on CH-NH Group DonorsAnimalsCell AdhesionEukaryotic Translation Initiation Factor 5AFemaleMaleMicePeptide Initiation FactorsProtein BiosynthesisProteomicsRibosomesRNA-Binding ProteinsSignal TransductionEukaryotic Translation Initiation Factor 5AOxidoreductases Acting on CH-NH Group DonorsPeptide Initiation FactorsRNA-Binding Proteins

Identifiers

PMID41565804
PMCPMC12999486

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.