Evidence map›Paper›PMID 41565808›Full record

ArticleNature2026

Pyramidal neurons proportionately alter cortical interneuron subtypes.

Sherry Jingjing Wu, Min Dai, Shang-Po Yang, Cai McCann, Yanjie Qiu, Vipin Kumar, Giovanni J Marrero, Jeremiah Tsyporin, Shuhan Huang, David Shin and 8 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
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  5. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Sherry Jingjing Wu *Department of Neurobiology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-9625-1661
Min Dai *Department of Neurobiology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-7584-5014
Shang-Po YangStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0009-0009-0634-4561
Cai McCannSpatial Technology Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0003-2010-9794
Yanjie QiuDepartment of Neurobiology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
Vipin KumarBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0003-2533-9089
Giovanni J MarreroBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0003-1587-3624
Jeremiah TsyporinMolecular, Cell, and Developmental Biology Department, University of California, Santa Cruz, CA, USA.
Shuhan HuangDepartment of Neurobiology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
David ShinStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Jeffrey A StogsdillStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Daniela J Di BellaStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0001-6141-3704
Qing XuCenter for Genomics & Systems Biology, New York University Abu Dhabi, Abu Dhabi, UAE.ORCID 0000-0001-9479-470X
Bin ChenMolecular, Cell, and Developmental Biology Department, University of California, Santa Cruz, CA, USA.ORCID 0000-0003-1962-3593
Samouil L FarhiSpatial Technology Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0003-1359-4568
Evan Z MacoskoStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0002-2794-5165
Fei ChenBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0003-2308-3649
Gord FishellDepartment of Neurobiology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA. gordon_fishell@hms.harvard.edu.ORCID 0000-0002-9640-9278

Funding

Lineage Progression of Cortical Neural Stem CellsR01NS089777 · NINDS · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI CHEN, BIN · 2015 to 2025
$4.7M
Transcriptional regulation of neuronal identity and connectivityR01MH094589 · NIMH · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI CHEN, BIN · 2011 to 2021
$3.7M
NIMH NIH HHS R01 MH094589NINDS NIH HHS R01 NS089777
6 · The paper itself

Abstract

The mammalian cerebral cortex comprises a complex neuronal network that maintains a precise balance between excitatory pyramidal neurons and inhibitory interneurons. Accumulating evidence indicates that specific interneuron subtypes form stereotyped microcircuits with distinct pyramidal neuron classes

Indexed as

Cerebral CortexInterneuronsPyramidal CellsAnimalsCell DeathCell DifferentiationCell SurvivalDNA-Binding ProteinsFemaleMaleMiceMutationNerve Tissue ProteinsParvalbuminsSomatostatinTranscription FactorsDNA-Binding ProteinsNerve Tissue ProteinsParvalbuminsSomatostatinTranscription FactorsZfp312 protein, mouse

Identifiers

PMID41565808

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.