Evidence map›Paper›PMID 41565821›Full record

ArticleNature2026

Identification of an allosteric site on the E3 ligase adapter cereblon.

Vanessa N Dippon, Zeba Rizvi, Anthony E Choudhry, Chun-Wa Chung, Ibrahim F Alkuraya, Wenqing Xu, Xavier B Tao, Anthony J Jurewicz, Jessica L Schneck, Wenqian Chen and 9 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Review
  3. AbioRxiv : the preprint server for biology · 2026
    Article
  4. Review
  5. Review
  6. Review
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Vanessa N DipponDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.ORCID 0009-0009-8434-732X
Zeba Rizvi *Department of Integrative Structural and Computational Biology, Scripps Research, La Jolla, CA, USA.ORCID 0000-0002-3510-4454
Anthony E Choudhry *GSK, Research Technologies, Collegeville, PA, USA.
Chun-Wa ChungGSK, Research Technologies, Stevenage, UK.ORCID 0000-0002-2480-3110
Ibrahim F AlkurayaDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.
Wenqing XuDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.ORCID 0000-0001-7385-3141
Xavier B TaoDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.ORCID 0009-0003-0964-2296
Anthony J JurewiczGSK, Research Technologies, Collegeville, PA, USA.
Jessica L SchneckGSK, Research Technologies, Collegeville, PA, USA.ORCID 0009-0007-2312-825X
Wenqian ChenDepartment of Integrative Structural and Computational Biology, Scripps Research, La Jolla, CA, USA.
Nicole M CurnuttDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.ORCID 0000-0003-3194-906X
Farah KabirDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.
Kwok-Ho ChanGSK, Research Technologies, Stevenage, UK.ORCID 0000-0002-6693-2682
Markus A QueisserGSK, Research Technologies, Stevenage, UK.ORCID 0000-0002-3368-3827
Caterina MusettiGSK, Research Technologies, Collegeville, PA, USA.
Han DaiGSK, Research Technologies, Collegeville, PA, USA.
Gabriel C LanderDepartment of Integrative Structural and Computational Biology, Scripps Research, La Jolla, CA, USA.ORCID 0000-0003-4921-1135
Andrew B BenowitzGSK, Research Technologies, Collegeville, PA, USA. andrew.b.benowitz@gsk.com.ORCID 0000-0002-9913-605X
Christina M WooDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA. cwoo@chemistry.harvard.edu.ORCID 0000-0001-8687-9105

Funding

Automated, optimized, intelligent data collection for cryo-EMR01GM143805 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI LANDER, GABRIEL C · 2021 to 2025
$4.7M
Developing graphene grids to overcome air-water-interface issuesR21GM154216 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI GROTJAHN, DANIELLE ANN · 2024 to 2025
$506k
National Science Foundation Graduate Research FellowshipNIGMS NIH HHS R01 GM143805NIGMS NIH HHS R21 GM154216
6 · The paper itself

Abstract

Cereblon (CRBN) is the target of thalidomide derivatives

Indexed as

Adaptor Proteins, Signal TransducingAllosteric SitePeptide HydrolasesUbiquitin-Protein LigasesAllosteric RegulationCrystallography, X-RayHumansLigandsModels, MolecularProtein BindingProteolysisThalidomideAdaptor Proteins, Signal TransducingCRBN protein, humanLigandsPeptide HydrolasesThalidomideUbiquitin-Protein Ligases

Identifiers

PMID41565821

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.