Evidence map›Paper›PMID 41565824›Full record

ArticleNature2026

Ageing promotes microglial accumulation of slow-degrading synaptic proteins.

Ian H Guldner, Viktoria P Wagner, Patricia Moran-Losada, Sophia M Shi, Sophia W Golub, Johannes F Hevler, Kelly Chen, Barbara T Meese, Ali Ghoochani, Ernst Pulido and 16 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Microglia extract neuronal proteolytic organelles via skoupocytosis.bioRxiv : the preprint server for biology · 2026
    Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Engulfment by brain macrophages in a short-lived vertebrate.bioRxiv : the preprint server for biology · 2026
    Article
  13. Article
  14. Ribosome Molecular Aging Shapes Translation Dynamics.bioRxiv : the preprint server for biology · 2026
    Article
  15. Review
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Ian H GuldnerDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Viktoria P WagnerDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-1957-0658
Patricia Moran-LosadaDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Sophia M ShiDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0001-6935-1034
Sophia W GolubDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Johannes F HevlerDepartment of Chemistry, Stanford University, Stanford, CA, USA.
Kelly ChenDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Barbara T MeeseChair for Clinical Bioinformatics, Saarland University, Saarbruecken, Germany.
Ali GhoochaniThe Institute for Chemistry, Engineering and Medicine for Human Health (Sarafan ChEM-H), Stanford University, Stanford, CA, USA.
Ernst PulidoDepartment of Bioengineering, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-3616-9743
Hamilton Se-Hwee OhWu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0001-8192-7593
Yann Le GuenDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0001-6649-8364
Nannan LuDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0003-0905-8199
Pui Shuen WongBiosciences Central Research Facility, The Hong Kong University of Science and Technology, Hong Kong, China.
Ning-Sum ToHong Kong Center for Neurodegenerative Diseases, Hong Kong, China.
Dylan GarceauThe Jackson Laboratory, Bar Harbor, ME, USA.
Zimin GuoDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0009-0005-2602-1007
Jian LuoDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-2064-8467
Carolyn R BertozziDepartment of Chemistry, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0003-4482-2754
Emma LundbergDepartment of Bioengineering, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0001-7034-0850
Monther Abu-RemailehThe Institute for Chemistry, Engineering and Medicine for Human Health (Sarafan ChEM-H), Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0003-3772-0477
Michael SasnerThe Jackson Laboratory, Bar Harbor, ME, USA.ORCID http://orcid.org/0000-0002-6612-6111
Andreas Keller *Chair for Clinical Bioinformatics, Saarland University, Saarbruecken, Germany.ORCID http://orcid.org/0000-0002-5361-0895
Andrew C Yang *Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA, USA.
Tom H Cheung *Biosciences Central Research Facility, The Hong Kong University of Science and Technology, Hong Kong, China.ORCID http://orcid.org/0000-0003-0796-5406
Tony Wyss-CorayDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA. twc@stanford.edu.ORCID http://orcid.org/0000-0001-5893-0831

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neurodegenerative diseases affect 1 in 12 people globally and remain incurable. Central to their pathogenesis is a loss of neuronal protein maintenance and the accumulation of protein aggregates with ageing

Identifiers

PMID41565824
PMCPMC12935553

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.