Observational studyEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2026
Importance of oxyphil cells for parathyroid hormone/calcium concentrations in primary hyperparathyroidism: a retrospective observational study.
Observational study in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundIn patients with primary hyperparathyroidism (pHPT), the importance of oxyphil cells for hormonal activity is uncertain.
methodsThis retrospective observational study analyzed the histopathological findings of postoperative specimens from patients with pHPT (single gland disease). The indication for surgery was based on increased plasma intact parathyroid hormone (iPTH) concentrations and the presence of symptoms typical of pHPT. To quantify approximate oxyphil cell content (OCC), we determined the percentage of oxyphil cells observed in each specimen. To quantify the approximate lesion volume, we determined the diameters of the fresh specimen (length, width, and height). Multiplying the lesion volume by the approximated relative OCC yielded an estimate of absolute OCC. Approximated absolute and relative OCC were then compared with preoperative plasma iPTH and calcium concentrations. Associations between these parameters were calculated using logistic or linear regression analysis.
resultsWe studied 76 patients with pHPT. Increasing approximate relative OCC predicted slightly lower calcium concentration (indirect non-linear association, adjusted estimate 0.71, 95% confidence interval (CI) 0.19-1.40, p = 0.044). However, only in large lesions (> 1.5 cm
conclusionIn patients with pHPT, a higher approximate OCC was associated with slightly lower calcium concentrations, possibly mediated by a counter regulatory effect on iPTH production, especially in large lesions.
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