ArticleBMC infectious diseases2026
Association between the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) and short-term outcomes in hepatitis B virus-related acute-on-chronic liver failure.
Article in BMC infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
backgroundHepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) is associated with dyslipidemia and inflammatory responses. However, the association between a novel comprehensive lipid parameter, the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR), and clinical outcomes in HBV-ACLF remains unclear. This study aimed to investigate the relationship between NHHR and 28- and 90-day transplant-free (TF) mortality among patients with HBV-ACLF.
methodsThis study retrospectively enrolled 452 patients with HBV-ACLF from the First Affiliated Hospital of Anhui Medical University between January 2017 and June 2024. Clinical data at admission and follow-up outcomes at 28 and 90 days were collected. Multivariable Cox regression and restricted cubic splines (RCS) were employed to investigate the association between NHHR and 28- and 90-day TF mortality. A segmented Cox proportional hazards model was applied to examine the threshold effect. Stratified analysis was conducted to evaluate the relationship between NHHR and prognosis across different subgroups. Receiver operating characteristic (ROC) curve analysis was performed to compare the predictive performance of NHHR with other lipid indicators. Kaplan–Meier survival curves were compared between groups using the log-rank test.
resultsMultivariable Cox regression and RCS analyses revealed a nonlinear relationship between NHHR and the risk of mortality. A segmented Cox model was exploratorily fitted to approximate the apparent change in slope, yielding estimated change-points of 10.87 for 28-day and 11.21 for 90-day TF mortality. The findings remained generally consistent across subgroup analyses. Compared with conventional lipid parameters, NHHR showed the highest AUC for predicting 28-day and 90-day TF mortality (0.756 and 0.748), with similar 1,000-bootstrap optimism-corrected AUCs (0.757 and 0.749), and its performance was not significantly different from the MELD or COSSH-ACLF II scores (all DeLong P > 0.05).
conclusionElevated NHHR was significantly associated with 28- and 90-day TF mortality in patients with HBV-ACLF. As an easily calculated index, NHHR may aid early risk stratification alongside established prognostic scores. CLINICAL TRIAL NUMBER: Not applicable.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.