Evidence map›Paper›PMID 41566245›Full record

ArticleBMC plant biology2026

Flagellin-derived peptide flg22 from non-pathogenic Pseudomonas fragi Sneb1990 triggers plant immunity and reduces Meloidogyne incognita infestation.

Shuangling Zhao, Shuai Wang, Yuanyuan Wang, Xiaoyu Liu, Ning Yang, Xiaofeng Zhu, Yuxi Duan, Haiyan Fan, Lijie Chen

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In one paragraph

Article in BMC plant biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Shuangling Zhao *Nematology Institute of Northern China, College of Plant Protection, Shenyang Agriculture University, Shenyang, China.
Shuai Wang *Key Laboratory of Green Prevention and Control of Tropical Plant Diseases and Pests, Ministry of Education, School of Plant Protection, Hainan University, Danzhou, China.
Yuanyuan WangCollege of Biological Science and Technology, Shenyang Agriculture University, Shenyang, China.
Xiaoyu LiuCollege of Sciences, Shenyang Agriculture University, Shenyang, 110866, China.
Ning YangNematology Institute of Northern China, College of Plant Protection, Shenyang Agriculture University, Shenyang, China.
Xiaofeng ZhuNematology Institute of Northern China, College of Plant Protection, Shenyang Agriculture University, Shenyang, China.
Yuxi DuanNematology Institute of Northern China, College of Plant Protection, Shenyang Agriculture University, Shenyang, China.
Haiyan FanNematology Institute of Northern China, College of Plant Protection, Shenyang Agriculture University, Shenyang, China. fanhaiyan2017@syau.edu.cn.
Lijie ChenNematology Institute of Northern China, College of Plant Protection, Shenyang Agriculture University, Shenyang, China. chenlj-0210@syau.edu.cn.

Funding

Liaoning Province Natural Science Foundation General Progra 2024-MS-091National Key Research and Development Program of China 2023YFD1400400National Natural Science Foundation of China 32372481National Parasitic Resources Center NPRC-2019-194-30
6 · The paper itself

Abstract

backgroundBiological control is widely recognized for its environmental benefits and has gained increasing attention. The peptide flg22 derived from biocontrol bacteria Pseudomonas fragi Sneb1990 (flg22Pf) exhibits significant efficacy against Meloidogyne incognita, but its mechanism is still unknown.

resultsIn this study, we cloned the full-length flagellin gene from P. fragi Sneb1990 and found that it shares 32.02% sequence identity with the flagellin from non-pathogenic Pseudomonas syringae pv. tomato DC3000 (Pst DC300). Compared to flg22 derived from Pst DC3000 (flg22Ps), flg22Pf contains an amino acid substitution at position 19. Growth inhibition assays in Arabidopsis seedlings confirmed that flg22Pf activates immunity in an FLS2-dependent manner. The Nicotiana benthamiana leaf inoculation experiments indicated that flg22Pf significantly induces the expression of immune-related genes PTI5 and WRKY7, thereby enhancing resistance against Pst DC3000 infection. Furthermore, tomato treatment with flg22Pf promoted H2O2 production, ROS accumulation, callose deposition, and lignin accumulation. Consequently, this induction of defense responses resulted in suppressed nematode infestation.

conclusionCollectively, our results reveal that flg22Pf from P. fragi Sneb1990 elicits a multi-layered immune response similar to flg22Ps, leading to an enhanced early immune response in tomato against M. incognita infestation. This study provides a novel plant immune-based strategy for sustainable M. incognita control.

Indexed as

FlagellinPlant ImmunityPseudomonas fragiSolanum lycopersicumTylenchoideaAnimalsArabidopsisHost-Parasite InteractionsPeptidesFlagellinflg22 flagellin-derived peptidePeptidesFlg22Immune responseMeloidogyne incognitaPseudomonas fragi Sneb1990

Identifiers

PMID41566245
PMCPMC12911367

What Socratic holds

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LicenceCC BY-NC-ND
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.