Trial reportBMC women's health2026
Ovarian reserve integrated damage (ORI) model for predicting ovarian function recovery after laparoscopic ovarian cystectomy for endometriosis: a randomized controlled trial.
Trial report in BMC women's health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Data mining and clinical observational study on the association between smoking and premature ovarian insufficiency.Frontiers in endocrinology · 2026Observational
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundLaparoscopic ovarian cystectomy for endometriosis carries a substantial risk of diminished ovarian reserve. Optimal intraoperative hemostasis remains uncertain, and predictive tools for postoperative ovarian function are limited.
methodsIn this prospective, randomized controlled trial, 101 women undergoing laparoscopic ovarian cystectomy were assigned to oxidised cellulose polymer, bipolar coagulation, or suturing for hemostasis. Primary endpoints were postoperative changes in anti-Müllerian hormone (AMH), antral follicle count (AFC), and peak systolic velocity (PSV). Two logistic regression–based Ovarian Reserve Index (ORI) models were developed: ORI-PreOp, using preoperative variables only, and ORI-PeriOp, incorporating both preoperative and intraoperative factors. The study design and reporting followed CONSORT 2010 guidelines for randomized trials and TRIPOD guidelines for prediction model development.
resultsA total of 173 patients were randomized to three hemostatic methods, with 101 completing the study. At 6 months, oxidised cellulose polymer preserved ovarian reserve more effectively than bipolar coagulation (AMH decline 5.97% vs. 19.06%; AFC decline 14.0% vs. 30.7%; PSV decline 5.3% vs. 20.0%; all P < 0.001) or suturing. The ORI-PeriOp model outperformed ORI-PreOp in predicting poor ovarian function recovery at 6 months (AUC 0.936 vs. 0.794) and 1 month (AUC 0.809 vs. 0.546). Incorporation of intraoperative variables significantly improved predictive accuracy.
conclusionsOxidised cellulose polymer offers superior preservation of ovarian reserve compared with bipolar coagulation or suturing in endometriosis-associated cystectomy. The ORI-PeriOp model provides reliable individualized risk stratification, facilitating tailored surgical planning and informed fertility counseling.
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