Evidence map›Paper›PMID 41566336›Full record

ArticleAlzheimer's research & therapy2026

Association of Alzheimer's disease biomarkers with malnutrition and altered body composition in cognitively impaired patients: a cross-sectional memory clinic study.

Karl Götze, Agathe Vrillon, Manuel Sanchez, Inès Petit-Damico, Elodie Bouaziz-Amar, Sophie Lacaille, Claire Hourrègue, Emmanuel Cognat, Jacques Hugon, Théodore Decaix and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's research & therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Karl GötzeInstitut Hospitalo-Universitaire ReConnect Université Paris Cité, 85, boulevard Saint-Germain, Paris, 75006, France. karl.gotze@aphp.fr.
Agathe VrillonInstitut Hospitalo-Universitaire ReConnect Université Paris Cité, 85, boulevard Saint-Germain, Paris, 75006, France.
Manuel SanchezGHU APHP Nord, Department of Geriatrics, Bretonneau Hospital, 23 rue Joseph de Maistre, Paris, 75018, France.
Inès Petit-DamicoGHU APHP Nord, Department of Geriatrics, Bretonneau Hospital, 23 rue Joseph de Maistre, Paris, 75018, France.
Elodie Bouaziz-AmarInstitut Hospitalo-Universitaire ReConnect Université Paris Cité, 85, boulevard Saint-Germain, Paris, 75006, France.
Sophie LacailleGHU APHP Nord, Department of Geriatrics, Bretonneau Hospital, 23 rue Joseph de Maistre, Paris, 75018, France.
Claire HourrègueInstitut Hospitalo-Universitaire ReConnect Université Paris Cité, 85, boulevard Saint-Germain, Paris, 75006, France.
Emmanuel CognatInstitut Hospitalo-Universitaire ReConnect Université Paris Cité, 85, boulevard Saint-Germain, Paris, 75006, France.
Jacques HugonUniversité Paris Cité, 85, boulevard Saint-Germain, Paris, 75006, France.
Théodore DecaixGHU APHP Nord, Geriatrics Department, Lariboisière-Fernand Widal Hospital, 200 rue du Faubourg Saint-Denis, Paris, 75010, France.
Julien DumurgierUniversité Paris Cité, 85, boulevard Saint-Germain, Paris, 75006, France.
Agathe Raynaud-SimonUniversité Paris Cité, 85, boulevard Saint-Germain, Paris, 75006, France.
Matthieu LilamandInstitut Hospitalo-Universitaire ReConnect Université Paris Cité, 85, boulevard Saint-Germain, Paris, 75006, France.
Claire PaquetInstitut Hospitalo-Universitaire ReConnect Université Paris Cité, 85, boulevard Saint-Germain, Paris, 75006, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionAlzheimer’s disease (AD) is marked by early weight loss, with unclear underlying mechanisms. Using real-world data, we aimed to investigate the links between biological AD profile, body composition, and nutritional status in patients with cognitive impairment.

methodsCross-sectional study of patients with cognitive decline who underwent cerebrospinal fluid (CSF) AD biomarkers and bioelectrical impedance analysis. Nutritional status was assessed using Global Leadership Initiative on Malnutrition (GLIM) criteria. Analyses were stratified by sex and adjusted for age, MMSE, comorbidities, and the presence of a caregiver at home.

resultsAmong 420 patients, 31.7% suffered from malnutrition which was associated with older age (p = .003), social isolation (p = .004), and lower MMSE scores (p = .010). Malnutrition was associated with higher pTau-181 (p = .018) and t-tau (p = .018) in women after adjustment for confounding factors. Lower Aβ42/40 ratio was associated with lower fat mass index in men (p < .001), whereas higher pTau-181 and t-tau were associated with lower fat mass index in women (p = .024 and p = .018).

conclusionThese results highlight the high prevalence of malnutrition in patients with cognitive disease from memory centers, and the association of AD CSF biomarkers with malnutrition and lower fat mass. Additional longitudinal and animal studies are needed to unravel this potential pathophysiological link.

Indexed as

Alzheimer DiseaseBody CompositionCognitive DysfunctionMalnutritionAgedAged, 80 and overAmyloid beta-PeptidesBiomarkersCross-Sectional StudiesElectric ImpedanceFemaleHumansMaleNutritional StatusPeptide Fragmentstau ProteinsAmyloid beta-Peptidesamyloid beta-protein (1-40)amyloid beta-protein (1-42)BiomarkersPeptide Fragmentstau ProteinsAlzheimer’s diseaseAmyloid beta-peptidesBody compositionElectric impedanceMalnutrition

Identifiers

PMID41566336
PMCPMC12918025

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.