Evidence map›Paper›PMID 41566363›Full record

ArticleJournal of nanobiotechnology2026

Clusterzymes-driven therapy: ultrasmall Cu

Yucheng Wang, Zeyu Han, Guanghua Hao, Han Cheng, Fengrong Dai, Xuzhuo Chen, Bin Shi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Multifunctional Vitamin BAntioxidants (Basel, Switzerland) · 2026
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yucheng Wang *Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Fujian Medical University, 20 Chazhong Road, Fuzhou, 350005, China.
Zeyu Han *Department of Oral Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine; College of Stomatology, Shanghai Jiao Tong University; National Center for Stomatology; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology; Shanghai Research Institute of Stomatology, The Ninth People's Hospital Affiliated to Shanghai Jiao Tong University, 639 Zhizaoju Road, Shanghai, 200011, China.
Guanghua Hao *Department of operating room, Linyi Central Hospital, Linyi, 276400, China.
Han ChengSchool of Physical Science and Technology, Shanghai Tech University, Shanghai, 201210, China.
Fengrong DaiState Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, 350005, China. dfr@fjirsm.ac.cn.
Xuzhuo ChenDepartment of Oral Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine; College of Stomatology, Shanghai Jiao Tong University; National Center for Stomatology; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology; Shanghai Research Institute of Stomatology, The Ninth People's Hospital Affiliated to Shanghai Jiao Tong University, 639 Zhizaoju Road, Shanghai, 200011, China. cxzzxcaa@126.com.
Bin ShiDepartment of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Fujian Medical University, 20 Chazhong Road, Fuzhou, 350005, China. shibin@fjmu.edu.cn.

Funding

Fujian Provincial Department of Science and Technology International Cooperation Project 2024I0014the National Natural Science Foundation of China Nos. 82301108, and 82370979
6 · The paper itself

Abstract

Inflammatory osteolysis represents a critical complication following orthopedic interventions such as total joint replacement, primarily triggered by persistent inflammatory responses induced by prosthetic wear debris or bacterial components like lipopolysaccharides (LPS). Inflammatory osteolysis, a severe complication of orthopedic interventions like total joint replacement, is driven by prosthetic wear debris or lipopolysaccharides (LPS)-induced persistent inflammation and osteoclast activation. Current therapeutic strategies are limited by significant side effects and their inability to simultaneously halt the synergistic pathological processes of inflammation and osteoclast activation, highlighting an urgent need for novel therapeutic approaches. In this study, we synthesized ultrasmall Cu₄ nanoclusters with potent superoxide dismutase (SOD)-and catalase (CAT)-mimetic activities, enabling efficient reactive oxygen species (ROS) scavenging (80.43%

Indexed as

AntioxidantsCopperFerroptosisOsteolysisAnimalsCatalaseInflammationLipopolysaccharidesMiceNF-E2-Related Factor 2OsteoclastsOxidative StressRAW 264.7 CellsReactive Oxygen SpeciesSuperoxide DismutaseAntioxidantsCatalaseCopperLipopolysaccharidesNF-E2-Related Factor 2Reactive Oxygen SpeciesSuperoxide DismutaseFerroptosisInflammatory osteolysisNanoclustersNrf2 pathwayOsteoclastROS

Identifiers

PMID41566363
PMCPMC12853966

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.