ArticleBMC genomics2026
Integrating reaction norm models and genome-wide association analyses to reveal the genetic architecture and environmental sensitivity of sexual precocity in Nellore cattle.
Article in BMC genomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundReproductive efficiency is an important component of profitability and sustainability in beef cattle production, particularly in tropical environments where animals are routinely exposed to environmental stressors. This study aimed to identify environmentally sensitive SNPs associated with sexual precocity traits in Nellore cattle and characterize candidate genes and biological pathways regulating sexual precocity under variable environmental conditions. For this purpose, three sexual precocity indicators were analyzed; one in heifers (heifer early calving probability at 30 months, HC30), and two in young males (scrotal circumference at 365 days, SC365; age at puberty, APM). Reaction norm models were integrated with genome-wide association studies (GWASs) to identify genomic regions associated with both genetic potential (intercept) and environmental sensitivity (slope).
resultsA total of 46 significant SNPs were identified across the three traits, with SC365 showing the highest genetic complexity (36 SNPs), followed by HC30 (7 SNPs), and APM (3 SNPs). The analyses revealed distinct genetic architectures among the traits. For HC30, candidate genes showed clear functional partitioning between those associated with baseline fertility (e.g., ERBB4, SNAI2) and those associated with environmental sensitivity (e.g., TRIB1, NSMCE2), with no overlap between intercept and slope components. In contrast, SC365 exhibited substantial genetic overlap, with five genes (i.e., GRB14, SLC9A8, SPATA2, MGRN1, SEPTIN12) significantly associated with both intercept and slope, indicating a robust trait with shared genetic control of baseline potential and environmental responsiveness. For APM, genetic associations were predominantly related to baseline potential, with genes involved in DNA repair (CHEK2), endoplasmic reticulum stress response (XBP1), and immune regulation (TNIP3). Functional enrichment analyses revealed trait-specific biological pathways, whereas QTL enrichment demonstrated biologically coherent overlaps with reproductive and metabolic traits.
conclusionThese findings demonstrate that sexual precocity traits exhibit distinct genetic architectures reflecting their underlying biological mechanisms and environmental responsiveness, providing valuable insights for developing climate-resilient breeding strategies in tropical beef cattle production systems.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.