Observational studyCritical care (London, England)2026
Passive leg raising and microvascular skin blood flow to predict peripheral tissue perfusion fluid responsiveness.
Observational study in Critical care (London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed.
- Physiological limits of capillary refill time: a human endotoxemia study.Critical care (London, England) · 2026Trial
- Beyond macrocirculatory targets: a multimodal framework for microcirculatory and organ perfusion monitoring in sepsis.Critical care (London, England) · 2026Review
- The usual suspects: a pragmatic framework to identify and address reversible contributors in apparent refractory septic shock.Critical care (London, England) · 2026Review
- Acute hemodynamic tests to determine the status of macro-to-microcirculatory coupling during septic shock resuscitation.Critical care (London, England) · 2026Article
- Passive leg raising, peripheral perfusion, and cardiac output: insights into hemodynamic coherence.Critical care (London, England) · 2026Article
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo assess whether skin blood flow (SBF) monitoring combined with passive leg raising (PLR) can predict microvascular fluid responsiveness in septic patients.
designProspective observational study.
settingSingle-center, 18-bed medical ICU in a tertiary university hospital in Paris, France. PATIENTS: Adult patients with sepsis requiring intravenous fluid administration.
interventionsPatients underwent a standardized PLR maneuver followed by a 500 mL saline fluid administration. Peripheral SBF was continuously monitored by fingertip laser Doppler flowmetry. MEASUREMENTS AND MAIN
resultsOf 37 patients included, 27 (73%) were classified as fluid responders, defined by a > 15% increase in SBF after volume expansion (ΔSBF-VE). In responders, SBF increased significantly during PLR (ΔSBF-PLR 40% [21-105]), while no significant changes were observed in non-responders. SBF variations induced by PLR (ΔSBF-PLR) strongly predicted fluid responsiveness with an AUROC of 0.95 [0.86-1.00] (P < 0.001). A ΔSBF-PLR threshold of > 6% identified responders with an 96 [80-100] % sensitivity and 90 [59-100] % specificity. Positive predictive value was 96 [80-100] % and negative predictive value was 91 [59-100]. Changes in SBF did not correlate with changes in cardiac output after volume expansion (R² =0.04, P = 0.28).
conclusionsIn septic patients, PLR-induced changes in SBF reliably predict peripheral microvascular responsiveness to a subsequent volume expansion. This simple, non-invasive approach may facilitate personalized fluid strategies aimed at optimizing microvascular tissue perfusion.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.