Evidence map›Paper›PMID 41566717›Full record

ArticleAutophagy2026

Lactucopicrin promotes the autophagic degradation of MAP2K4/MKK4 by mediating CCDC50 palmitoylation to alleviate osteoarthritis progression.

Wenjun Li, Qijie Sun, Konghe Hu, Dongmei Tang, Cheng Yang, Yingchao Xie, Xiaodong Peng, Yongtao Deng, Jiansen Lu, Yong Qi and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Autophagy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Wenjun LiDepartment of Orthopedics, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, China.
Qijie SunDepartment of Orthopedics, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, China.
Konghe HuDepartment of Orthopaedics, The State Key Clinical Specialty in Orthopaedics, Yuebei People's Hospital, Affiliated to Shantou University Medical College, Shaoguan, China.
Dongmei TangDepartment of Orthopaedics, The State Key Clinical Specialty in Orthopaedics, Yuebei People's Hospital, Affiliated to Shantou University Medical College, Shaoguan, China.
Cheng YangDepartment of Urology, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China.
Yingchao XieDepartment of Immunology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China.
Xiaodong PengDepartment of Orthopaedics, The State Key Clinical Specialty in Orthopaedics, Yuebei People's Hospital, Affiliated to Shantou University Medical College, Shaoguan, China.
Yongtao DengDepartment of Orthopaedics, The State Key Clinical Specialty in Orthopaedics, Yuebei People's Hospital, Affiliated to Shantou University Medical College, Shaoguan, China.
Jiansen LuDepartment of Joint Surgery, Shaoguan First People's Hospital, Southern Medical University, Shaoguan, China.
Yong QiDepartment of Orthopedics, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, China.
Yifen LinDepartment of Orthopedics, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, China.
Hongtao SunDepartment of Orthopedics, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, China.
Qinyu TianDepartment of Orthopaedics and Traumatology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China.
Changpeng XuDepartment of Orthopedics, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, China.ORCID 0000-0001-6349-0842
Xinggui TianUniversity Center of Orthopaedic, Trauma and Plastic Surgery, University Hospital Carl Gustav Carus at TUD Dresden University of Technology, Dresden, Germany.ORCID 0000-0003-3619-3943
Huaji JiangDepartment of Orthopaedics, The State Key Clinical Specialty in Orthopaedics, Yuebei People's Hospital, Affiliated to Shantou University Medical College, Shaoguan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Macroautophagy/autophagy plays a crucial role in maintaining cellular homeostasis and protecting against osteoarthritis (OA). Its dysregulation contributes to OA progression by promoting chondrocyte senescence, inflammation, and cartilage degradation. Enhancing autophagic activity thus represents a promising therapeutic strategy for OA. In this study, we identified lactucopicrin (LCP) as an effective autophagy activator that alleviates OA progression in a mouse model induced by the destabilization of the medial meniscus, by reducing cartilage degeneration and preserving matrix integrity. Mechanistically, LCP enhances ZDHHC4-catalyzed palmitoylation of the cargo receptor CCDC50, facilitating the selective autophagic degradation of MAP2K4/MKK4, leading to the suppression of MAPK/JNK signaling and the attenuation of chondrocyte senescence. Structural analysis reveals that LCP directly binds to His72 of ZDHHC4

Indexed as

AutophagyDisease ProgressionLipoylationMAP Kinase Kinase 4OsteoarthritisAcyltransferasesAnimalsCellular SenescenceChondrocytesHumansMiceMice, Inbred C57BLProteolysisAcyltransferasesMAP Kinase Kinase 4AutophagyCCDC50chondrocyte senescenceMAP2K4/MKK4osteoarthritispalmitoylation

Identifiers

PMID41566717
PMCPMC12931897

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.